rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
5
|
pubmed:dateCreated |
2001-5-4
|
pubmed:abstractText |
Radiolabeling monoclonal antibodies (mAbs) allows the evaluation of biodistribution of constructs in vivo through gamma camera imaging and also permits quantitation of mAb uptake in tumors through biopsy-based counting techniques. The quantitation of radiolabeled mAb uptake in cancer patients is complicated by the attenuation of gamma emissions of routinely used isotopes (e.g., 131I and 111In) and the spatial resolution and sensitivity of gamma cameras.
|
pubmed:commentsCorrections |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/GPA33 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Gpa33 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Iodine Radioisotopes,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins
|
pubmed:status |
MEDLINE
|
pubmed:month |
May
|
pubmed:issn |
0161-5505
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
42
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
764-9
|
pubmed:dateRevised |
2005-11-17
|
pubmed:meshHeading |
pubmed-meshheading:11337573-Animals,
pubmed-meshheading:11337573-Antibodies, Monoclonal,
pubmed-meshheading:11337573-Antigens, Neoplasm,
pubmed-meshheading:11337573-Colorectal Neoplasms,
pubmed-meshheading:11337573-Female,
pubmed-meshheading:11337573-Humans,
pubmed-meshheading:11337573-Iodine Radioisotopes,
pubmed-meshheading:11337573-Membrane Glycoproteins,
pubmed-meshheading:11337573-Mice,
pubmed-meshheading:11337573-Mice, Inbred BALB C,
pubmed-meshheading:11337573-Mice, Nude,
pubmed-meshheading:11337573-Neoplasm Transplantation,
pubmed-meshheading:11337573-Radioimmunodetection,
pubmed-meshheading:11337573-Recombinant Proteins,
pubmed-meshheading:11337573-Tissue Distribution,
pubmed-meshheading:11337573-Tomography, Emission-Computed
|
pubmed:year |
2001
|
pubmed:articleTitle |
Immuno-PET of human colon xenograft- bearing BALB/c nude mice using 124I-CDR-grafted humanized A33 monoclonal antibody.
|
pubmed:affiliation |
Melbourne Tumor Biology Branch, Ludwig Institute for Cancer Research, and Centre for PET, Austin & Repatriation Medical Centre, Heidelberg, Victoria, Australia.
|
pubmed:publicationType |
Journal Article
|