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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2001-5-4
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pubmed:abstractText |
Retinoblastoma (Rb) protein promotes cell survival after DNA damage. We show here that the LxCxE binding site in Rb mediates both cell survival and cell-cycle arrest after DNA damage. Replication factor C (RF-C) complex plays an important role in DNA replication. We describe a novel function of the large subunit of RF-C in promoting cell survival after DNA damage. RF-Cp145 contains an LxCxE motif, and mutation of this motif abolishes the protective effect of RF-Cp145. The inability of wild-type RF-Cp145 to promote cell survival in Rb-null cells is rescued by Rb but not by Rb mutants defective in binding LxCxE proteins. RF-C thus enhances cell survival after DNA damage in an Rb-dependent manner.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/BCL2-related protein A1,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/HDAC1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Histone Deacetylases,
http://linkedlifedata.com/resource/pubmed/chemical/Homeodomain Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/MATA1 protein, S cerevisiae,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Proto-Oncogene Proteins c-bcl-2,
http://linkedlifedata.com/resource/pubmed/chemical/Replication Protein C,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Retinoblastoma Protein,
http://linkedlifedata.com/resource/pubmed/chemical/SMARCA4 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Saccharomyces cerevisiae Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1097-2765
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pubmed:author |
pubmed-author:BricknerHH,
pubmed-author:ChenT TTT,
pubmed-author:DickFF,
pubmed-author:DysonNN,
pubmed-author:FotedarAA,
pubmed-author:FotedarRR,
pubmed-author:MunshiAA,
pubmed-author:PennaneachVV,
pubmed-author:RegazzoniKK,
pubmed-author:Salles-PassadorII,
pubmed-author:WangJ YJY
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
715-27
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11336696-Amino Acid Motifs,
pubmed-meshheading:11336696-Animals,
pubmed-meshheading:11336696-Binding Sites,
pubmed-meshheading:11336696-COS Cells,
pubmed-meshheading:11336696-Cell Cycle,
pubmed-meshheading:11336696-Cell Survival,
pubmed-meshheading:11336696-DNA Damage,
pubmed-meshheading:11336696-DNA Helicases,
pubmed-meshheading:11336696-DNA-Binding Proteins,
pubmed-meshheading:11336696-Female,
pubmed-meshheading:11336696-Histone Deacetylase 1,
pubmed-meshheading:11336696-Histone Deacetylases,
pubmed-meshheading:11336696-Homeodomain Proteins,
pubmed-meshheading:11336696-Humans,
pubmed-meshheading:11336696-Mutagenesis,
pubmed-meshheading:11336696-Nuclear Proteins,
pubmed-meshheading:11336696-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:11336696-Replication Protein C,
pubmed-meshheading:11336696-Repressor Proteins,
pubmed-meshheading:11336696-Retinoblastoma Protein,
pubmed-meshheading:11336696-Saccharomyces cerevisiae Proteins,
pubmed-meshheading:11336696-Transcription Factors,
pubmed-meshheading:11336696-Transfection,
pubmed-meshheading:11336696-Tumor Cells, Cultured,
pubmed-meshheading:11336696-Ultraviolet Rays,
pubmed-meshheading:11336696-Uterine Cervical Neoplasms
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pubmed:year |
2001
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pubmed:articleTitle |
The large subunit of replication factor C promotes cell survival after DNA damage in an LxCxE motif- and Rb-dependent manner.
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pubmed:affiliation |
Sidney Kimmel Cancer Center, 10835 Altman Road, San Diego, CA 92121, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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