Linked Life Data

11336297

Source:http://linkedlifedata.com/resource/pubmed/id/11336297

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2001-5-4
pubmed:abstractText
To evaluate the biocompatibility of refractory metals, titanium, hafnium, niobium, tantalum and rhenium were implanted in rats, and histological observation and elemental mapping were performed by X-ray scanning analytical microscope (XSAM) and electron probe microanalyzer (EPMA). The titanium, hafnium, niobium, tantalum and rhenium wires were implanted in the subcutaneous tissue of the abdominal region and in femoral bone marrow of rats for either 2 or 4 weeks. No inflammatory response was observed around the implants, and all the implants were encapsulated with thin fibrous connective tissue. No dissolution of these metals was detected by XSAM in the soft tissue. Histological examination of the hard tissue showed that the amount of new bone formation decreased slightly from the second to the fourth week after implantation, and that the percentage of bone in contact with the implant increased markedly over the same period. No dissolution of these metals was detected by EPMA in the hard tissue. The Ca and P intensities in the mapping images of newly formed bone were higher after 4 weeks than those after 2 weeks, which suggests that the newly formed bone continued to mature from 2 to 4 weeks after implantation. These results indicate that titanium, hafnium, niobium, tantalum and rhenium have good biocompatibility and osteoconductivity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0142-9612
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1253-62
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Biocompatibility and osteogenesis of refractory metal implants, titanium, hafnium, niobium, tantalum and rhenium.
pubmed:affiliation
Department of Removable Prosthetic Dentistry, School of Dentistry, Hokkaido University, Sapporo, Japan. goma@den.hokudai.ac.jp
pubmed:publicationType
Journal Article, Evaluation Studies