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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4 Pt 1
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pubmed:dateCreated |
2001-5-4
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pubmed:abstractText |
The response to exogenous administration of acetylcholine and the effects of nitric oxide (NO) synthesis blockade were assessed for small arterioles in the cremaster muscle of deoxycorticosterone acetate (DOCA)-salt hypertensive and normotensive rats using intravital microscopy. The NO synthesis inhibitor N omega-L-nitro-arginine methyl ester (L-NAME) produced significantly less constriction in the arterioles of DOCA-salt hypertensive rats. Exposure to increasing concentrations of acetylcholine (10(-10) to 10(-5) mol/L) or sodium nitroprusside (10(-10) to 10(-5) mol/L) produced similar arteriolar dilation in both groups. These results suggest that attenuated basal release of NO by arterioles may play a role in the development of increased peripheral resistance observed in DOCA-salt hypertension.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0895-7061
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
387-9
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pubmed:dateRevised |
2009-2-24
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pubmed:meshHeading |
pubmed-meshheading:11336187-Acetylcholine,
pubmed-meshheading:11336187-Animals,
pubmed-meshheading:11336187-Arterioles,
pubmed-meshheading:11336187-Desoxycorticosterone,
pubmed-meshheading:11336187-Enzyme Inhibitors,
pubmed-meshheading:11336187-Hypertension,
pubmed-meshheading:11336187-Male,
pubmed-meshheading:11336187-Muscle, Skeletal,
pubmed-meshheading:11336187-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:11336187-Nitric Oxide,
pubmed-meshheading:11336187-Nitric Oxide Donors,
pubmed-meshheading:11336187-Nitric Oxide Synthase,
pubmed-meshheading:11336187-Nitroprusside,
pubmed-meshheading:11336187-Rats,
pubmed-meshheading:11336187-Rats, Sprague-Dawley,
pubmed-meshheading:11336187-Reference Values,
pubmed-meshheading:11336187-Sodium Chloride,
pubmed-meshheading:11336187-Vasodilation,
pubmed-meshheading:11336187-Vasodilator Agents
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pubmed:year |
2001
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pubmed:articleTitle |
Decreased influence of nitric oxide on deoxycorticosterone acetate (DOCA)-salt hypertension.
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pubmed:affiliation |
Department of Pediatrics, University of Louisville School of Medicine, Kentucky, USA.
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pubmed:publicationType |
Journal Article
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