Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-5-3
pubmed:abstractText
From July 1994 to December 1996, 41 patients with previously untreated, advanced bulky squamous cell carcinoma arising from the buccal mucosa (BSCC) were enrolled. All patients were males with a median age of 47 years (range 29-72). The tumor extent was stage III/IV: three of 38, T4: 85%, N2-3: 20%. Patients were initially scheduled to receive intra-arterial (i.a.) chemotherapy, followed by i.v. chemotherapy and regional therapy. The i.a. chemotherapy catheter was properly placed by external carotid artery angiography via the femoral artery. The i.a. chemotherapy consisted of cisplatin (P) 100 mg/m(2) day 1 plus 5-fluorouracil (F) 1000 mg/m(2) day 1-4, and the i.v. chemotherapy consisted of PF (10 patients) or PF plus methotrexate 200 mg/m(2) day 15 and 22 (31 patients). All chemotherapy regimens were administered at 4-week intervals. The response rate of i.a. plus i.v. chemotherapy for the primary site was 85% (35 of 41) with 29% complete remission (CR) (12 of 41). The response and CR rates of neck nodes were 82% (14 of 17) and 41% (seven of 17), respectively. The combined overall response rate was 80% (33 of 41) with a 29% CR (12 of 41). Major toxicity from i.a. chemotherapy of WHO grade > or = 3 included: mucositis of infusion area (76%), hemialopecia (56%) and leukopenia (5%). Three neurologic complications of i.a. chemotherapy including one hemiparesis occurred. The median follow-up time was 47 months (range 36-66 months), and the overall survival and disease-free survival were both 34% (14 of 41). Four patients were cured with chemotherapy alone and eight patients (19.5%) were cured without surgical intervention. Using i.a. chemotherapy as a cytoreductive therapy followed by subsequent i.v. chemotherapy produces a high response rate and an encouraging degree of complete response rate in advanced bulky BSCC. However, toxicity management and catheter placement will need to be improved in order to better define the role of this therapy in advanced BSCC.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0959-4973
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-7
pubmed:dateRevised
2006-4-24
pubmed:meshHeading
pubmed-meshheading:11335789-Adult, pubmed-meshheading:11335789-Aged, pubmed-meshheading:11335789-Alopecia, pubmed-meshheading:11335789-Antineoplastic Combined Chemotherapy Protocols, pubmed-meshheading:11335789-Carcinoma, Squamous Cell, pubmed-meshheading:11335789-Cisplatin, pubmed-meshheading:11335789-Drug Administration Schedule, pubmed-meshheading:11335789-Drug Eruptions, pubmed-meshheading:11335789-Dyspnea, pubmed-meshheading:11335789-Fluorouracil, pubmed-meshheading:11335789-Humans, pubmed-meshheading:11335789-Infusions, Intra-Arterial, pubmed-meshheading:11335789-Infusions, Intravenous, pubmed-meshheading:11335789-Lymphatic Metastasis, pubmed-meshheading:11335789-Male, pubmed-meshheading:11335789-Methotrexate, pubmed-meshheading:11335789-Middle Aged, pubmed-meshheading:11335789-Mouth Mucosa, pubmed-meshheading:11335789-Mouth Neoplasms, pubmed-meshheading:11335789-Neoplasm Recurrence, Local, pubmed-meshheading:11335789-Radiotherapy, Adjuvant, pubmed-meshheading:11335789-Stomatitis, pubmed-meshheading:11335789-Survival Rate, pubmed-meshheading:11335789-Treatment Outcome
pubmed:year
2001
pubmed:articleTitle
Intra-arterial plus i.v. chemotherapy for advanced bulky squamous cell carcinoma of the buccal mucosa.
pubmed:affiliation
Division of Hematology/Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Taipei, Taiwan, ROC.
pubmed:publicationType
Journal Article, Clinical Trial