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rdf:type |
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lifeskim:mentions |
umls-concept:C0004083,
umls-concept:C0017337,
umls-concept:C0022658,
umls-concept:C0030705,
umls-concept:C0205179,
umls-concept:C0220908,
umls-concept:C0332307,
umls-concept:C0597357,
umls-concept:C0598528,
umls-concept:C0679058,
umls-concept:C1547699,
umls-concept:C1882417,
umls-concept:C2603343,
umls-concept:C2700640
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pubmed:issue |
5
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pubmed:dateCreated |
2001-5-3
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pubmed:abstractText |
Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy. The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and was associated with a longer duration of nephropathy-free diabetes (P = 0.08).
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0012-1797
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1214-8
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11334430-5' Untranslated Regions,
pubmed-meshheading:11334430-Adolescent,
pubmed-meshheading:11334430-Adult,
pubmed-meshheading:11334430-Age of Onset,
pubmed-meshheading:11334430-Chromosome Mapping,
pubmed-meshheading:11334430-Chromosomes, Human, Pair 1,
pubmed-meshheading:11334430-Chromosomes, Human, Pair 14,
pubmed-meshheading:11334430-Chromosomes, Human, Pair 19,
pubmed-meshheading:11334430-Chromosomes, Human, Pair 6,
pubmed-meshheading:11334430-Diabetes Mellitus, Type 1,
pubmed-meshheading:11334430-Diabetic Nephropathies,
pubmed-meshheading:11334430-Genetic Testing,
pubmed-meshheading:11334430-Glycosylation End Products, Advanced,
pubmed-meshheading:11334430-Homozygote,
pubmed-meshheading:11334430-Humans,
pubmed-meshheading:11334430-Point Mutation,
pubmed-meshheading:11334430-Polymorphism, Genetic,
pubmed-meshheading:11334430-Promoter Regions, Genetic,
pubmed-meshheading:11334430-Protein Isoforms,
pubmed-meshheading:11334430-Receptors, Immunologic
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pubmed:year |
2001
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pubmed:articleTitle |
Polymorphism screening of four genes encoding advanced glycation end-product putative receptors. Association study with nephropathy in type 1 diabetic patients.
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pubmed:affiliation |
Institut National de la Santé et de la Recherche Médicale INSERM U525/SC7, Paris, France.
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pubmed:publicationType |
Journal Article,
Comparative Study
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