11333981

Source:http://linkedlifedata.com/resource/pubmed/id/11333981

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0029266, umls-concept:C0042817, umls-concept:C0205234, umls-concept:C0678558
pubmed:issue	6833
pubmed:dateCreated	2001-5-3
pubmed:abstractText	Cortical areas are generally assumed to be uniform in their capacity for adaptive changes or plasticity. Here we demonstrate, however, that neurons in the cat striate cortex (V1) show pronounced adaptation-induced short-term plasticity of orientation tuning primarily at specific foci. V1 neurons are clustered according to their orientation preference in iso-orientation domains that converge at singularities or pinwheel centres. Although neurons in pinwheel centres have similar orientation tuning and responses to those in iso-orientation domains, we find that they differ markedly in their capacity for adaptive changes. Adaptation with an oriented drifting grating stimulus alters responses of neurons located at and near pinwheel centres to a broad range of orientations, causing repulsive shifts in orientation preference and changes in response magnitude. In contrast, neurons located in iso-orientation domains show minimal changes in their tuning properties after adaptation. The anisotropy of adaptation-induced orientation plasticity is probably mediated by inhomogeneities in local intracortical interactions that are overlaid on the map of orientation preference in V1.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/0410462
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	May
pubmed:issn	0028-0836
pubmed:author	pubmed-author:DragonKK, pubmed-author:RivadullaCC, pubmed-author:SurMM
pubmed:issnType	Print
pubmed:day	3
pubmed:volume	411
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	80-6
pubmed:dateRevised	2006-11-15
pubmed:meshHeading	pubmed-meshheading:11333981-Animals, pubmed-meshheading:11333981-Cats, pubmed-meshheading:11333981-Electrophysiology, pubmed-meshheading:11333981-Neuronal Plasticity, pubmed-meshheading:11333981-Neurons, pubmed-meshheading:11333981-Visual Cortex
pubmed:year	2001
pubmed:articleTitle	Foci of orientation plasticity in visual cortex.
pubmed:affiliation	Department of Brain and Cognitive Sciences and Center for Learning and Memory, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA. vdragoi@ai.mit.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't