Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
2001-4-30
pubmed:abstractText
Taurine acts as an antioxidant protecting neurons from free radical-mediated cellular damage. 3-nitropropionic acid (3-NP) inhibits energy metabolism, initiating oxidative stress. With the objective to examine whether taurine can protect glia and neurons from damage produced by 3-NP, male Wistar and Sprague-Dawley rats were treated with either (1) saline, (2) taurine (3) 3-NP and saline, or (4) 3-NP and taurine for 4 days. Survival was determined and brains were processed immunohistochemically. Large striatal lesions and increased GFAP, SOD, and taurine immunoreactivity were detected in the 3-NP group when compared with control groups. In contrast, animals receiving 3-NP and taurine exhibited less GFAP, SOD, and taurine immunoreactivity, along with increased survival rates. Results indicate that taurine treatment after 3-NP administration protects the striatum from damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0020-7454
pubmed:author
pubmed:issnType
Print
pubmed:volume
108
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
55-67
pubmed:dateRevised
2005-11-17
pubmed:meshHeading
pubmed-meshheading:11328702-Animals, pubmed-meshheading:11328702-Antioxidants, pubmed-meshheading:11328702-Astrocytes, pubmed-meshheading:11328702-Convulsants, pubmed-meshheading:11328702-Corpus Striatum, pubmed-meshheading:11328702-Glial Fibrillary Acidic Protein, pubmed-meshheading:11328702-Immunohistochemistry, pubmed-meshheading:11328702-Male, pubmed-meshheading:11328702-Neurons, pubmed-meshheading:11328702-Neuroprotective Agents, pubmed-meshheading:11328702-Nitro Compounds, pubmed-meshheading:11328702-Propionic Acids, pubmed-meshheading:11328702-Random Allocation, pubmed-meshheading:11328702-Rats, pubmed-meshheading:11328702-Rats, Sprague-Dawley, pubmed-meshheading:11328702-Rats, Wistar, pubmed-meshheading:11328702-Superoxide Dismutase, pubmed-meshheading:11328702-Survival Rate, pubmed-meshheading:11328702-Taurine
pubmed:year
2001
pubmed:articleTitle
Taurine increases rat survival and reduces striatal damage caused by 3-nitropropionic acid.
pubmed:affiliation
Dept. of Neurosurgery, College of Medicine, University of South Florida, Tampa, FL 33612, USA. srivas@servidor.unam.mx
pubmed:publicationType
Journal Article