Linked Life Data

11328693

Source:http://linkedlifedata.com/resource/pubmed/id/11328693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3-4
pubmed:dateCreated
2001-4-30
pubmed:abstractText
1 H Magnetic resonance spectroscopic imaging (MRSI) and positron emission tomography (PET) of (18) F-2-fluoro-2-deoxy-D-glucose (FDG) were performed in 18 patients with probable Alzheimer's disease (AD) and 3 normal controls. We measured the distribution and relative signal intensities of N-acetyl aspartate (NAA; a presumed neuronal marker), choline residues (Cho) representing cellular membrane compounds and of creatine-containing metabolites (Cr), and correlated these to regional cerebral glucose metabolism (rCMRGI) after coregistration of both imaging-techniques. The pattern of choline was significantly different between AD and normals (p < 0.01). RCMRGI was significantly related to Cho/Cr (r=-0.21, p<.05) and NAA/Cho quotients (r=0.35, p<.001). Our results suggest that in AD reduced neuronal energy performance and membrane abnormalities contribute to metabolic deterioration.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0020-7454
pubmed:author
pubmed:issnType
Print
pubmed:volume
107
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-45
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Relation between 1H MR spectroscopic imaging and regional cerebral glucose metabolism in Alzheimer's disease.
pubmed:affiliation
Max-Planck Institute for Neurological Research, Gleueler Str. 50, D-50931 Köln, Germany. ruediger.mielke@pet.mpin-koeln.mpg.de
pubmed:publicationType
Journal Article