Linked Life Data

11328293

Source:http://linkedlifedata.com/resource/pubmed/id/11328293

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-4-30
pubmed:abstractText
The role of the host immune compartment in the control of chronic myeloid leukaemia (CML) has been suggested by numerous biological and clinical evidence. In the present study, the phenotypic and functional machinery of both T and cytotoxic lymphocytes was evaluated in a series of CML patients in complete haematological, and frequently also in cytogenetic, remission after treatment with interferon (IFN) alpha or hydroxyurea, and compared with the profile observed in patients at diagnosis and in normal controls. In particular, the lymphocyte subset distribution, the cytotoxic activity and the intracellular production of tumour necrosis factor (TNF)alpha and IFN gamma by CD4(+), CD8(+) and CD56(+) cells were investigated. CML patients in complete haematological remission showed a normalized CD4/CD8 T-cell subset distribution, as well as a restored spontaneous and interleukin 2 (IL-2) induced cytotoxic function compared with the pattern observed at diagnosis. This was associated with a significantly increased proportion of activated CD4(+) lymphocytes (CD25(+)). TNF alpha and IFN gamma production by CD4(+), CD8(+) and CD56(+) lymphocytes was significantly enhanced compared with that of patients at diagnosis. However, the values were lower than those of normal controls. These results indicate that, in contrast to the observations at presentation, CML patients, at the time of the best possible response to treatment, show a normalized T-cell subset distribution associated with an activated CD4 T-cell compartment and a restored cytotoxic activity. In addition, they also show a markedly increased intracellular cytokine production by the lymphoid populations that play an important role in the process of specific tumour recognition. The design of therapeutic strategies aimed at stimulating the host immune compartment finds a further rationale for CML patients responsive to treatment with both IFN alpha and hydroxyurea.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0007-1048
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
136-42
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11328293-Adult, pubmed-meshheading:11328293-Aged, pubmed-meshheading:11328293-Antigens, CD56, pubmed-meshheading:11328293-CD4-CD8 Ratio, pubmed-meshheading:11328293-CD4-Positive T-Lymphocytes, pubmed-meshheading:11328293-CD8-Positive T-Lymphocytes, pubmed-meshheading:11328293-Case-Control Studies, pubmed-meshheading:11328293-Cytotoxicity Tests, Immunologic, pubmed-meshheading:11328293-Female, pubmed-meshheading:11328293-Humans, pubmed-meshheading:11328293-Hydroxyurea, pubmed-meshheading:11328293-Immunophenotyping, pubmed-meshheading:11328293-Interferon-alpha, pubmed-meshheading:11328293-Interferon-gamma, pubmed-meshheading:11328293-Interleukin-2, pubmed-meshheading:11328293-Killer Cells, Natural, pubmed-meshheading:11328293-Leukemia, Myelogenous, Chronic, BCR-ABL Positive, pubmed-meshheading:11328293-Lymphocyte Activation, pubmed-meshheading:11328293-Male, pubmed-meshheading:11328293-Middle Aged, pubmed-meshheading:11328293-Receptors, Interleukin-2, pubmed-meshheading:11328293-Remission Induction, pubmed-meshheading:11328293-T-Lymphocytes, pubmed-meshheading:11328293-Tumor Necrosis Factor-alpha
pubmed:year
2001
pubmed:articleTitle
Phenotypic and functional characterization of the host immune compartment of chronic myeloid leukaemia patients in complete haematological remission.
pubmed:affiliation
Dipartimento di Biotecnologie Cellulari ed Ematologia, University La Sapienza, Rome, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't