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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-4-30
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pubmed:abstractText |
The structure activity relationship on a series of ester and hydroxamate analogues of methionyl and isoleucyl adenylate has been investigated through introducing linkers between the 1'-position of ribose and adenine surrogates as methionyl-tRNA, and isoleucyl-tRNA synthetase inhibitors, respectively. The results indicate that ester analogue 23 was found to be a potent inhibitor of Escherichia coli methionyl-tRNA synthetase, and its interaction with the active site was proposed by a molecular modeling study.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
961-4
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11327600-Adenosine,
pubmed-meshheading:11327600-Adenosine Monophosphate,
pubmed-meshheading:11327600-Binding Sites,
pubmed-meshheading:11327600-Escherichia coli,
pubmed-meshheading:11327600-Esters,
pubmed-meshheading:11327600-Hydroxamic Acids,
pubmed-meshheading:11327600-Isoleucine,
pubmed-meshheading:11327600-Isoleucine-tRNA Ligase,
pubmed-meshheading:11327600-Methionine,
pubmed-meshheading:11327600-Methionine-tRNA Ligase,
pubmed-meshheading:11327600-Models, Molecular,
pubmed-meshheading:11327600-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
Ester and hydroxamate analogues of methionyl and isoleucyl adenylates as inhibitors of methionyl-tRNA and isoleucyl-tRNA synthetases.
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pubmed:affiliation |
Laboratory of Medicinal Chemistry, College of Pharmacy, Seoul National University, Kwanak-Ku, South Korea. jeewoo@snu.ac.kr
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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