rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
8
|
pubmed:dateCreated |
2001-4-30
|
pubmed:abstractText |
A lipophilicity constrained library of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles was prepared by solution-phase parallel synthesis with removal of acidic by-products using the strongly basic MP-carbonate resin. Compounds show both activation of soluble guanylate cyclase and inhibition of platelet aggregation. Compound 12 also shows 22% oral bioavailability in rats.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0960-894X
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
23
|
pubmed:volume |
11
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1089-92
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:11327597-Administration, Oral,
pubmed-meshheading:11327597-Animals,
pubmed-meshheading:11327597-Biological Availability,
pubmed-meshheading:11327597-Collagen,
pubmed-meshheading:11327597-Cyclic GMP,
pubmed-meshheading:11327597-Enzyme Activators,
pubmed-meshheading:11327597-Guanylate Cyclase,
pubmed-meshheading:11327597-Inhibitory Concentration 50,
pubmed-meshheading:11327597-Platelet Aggregation,
pubmed-meshheading:11327597-Pyrazoles,
pubmed-meshheading:11327597-Rats
|
pubmed:year |
2001
|
pubmed:articleTitle |
Solution-Phase parallel synthesis of 5-carboxamido 1-benzyl-3-(3-dimethylaminopropyloxy)-1H-pyrazoles as activators of soluble guanylate cyclase with improved oral bioavailability.
|
pubmed:affiliation |
Biological & Medicinal Chemistry, The Wolfson Institute For Biomedical Research, University College London, UK. d.selwood@ucl.ac.uk
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|