Source:http://linkedlifedata.com/resource/pubmed/id/11327591
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
8
|
| pubmed:dateCreated |
2001-4-30
|
| pubmed:abstractText |
A series of N-acyloxymethyl- and N-aminocarbonyloxymethyl derivatives of 2-azetidinones, 3, with different substituent patterns at the beta-lactam C-3 and C-4 positions, were designed as potential mechanism-based inhibitors for human leukocyte elastase and found to exhibit inhibitory potency and selectivity for the enzyme.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0960-894X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
23
|
| pubmed:volume |
11
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1065-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11327591-Azetidines,
pubmed-meshheading:11327591-Drug Design,
pubmed-meshheading:11327591-Drug Stability,
pubmed-meshheading:11327591-Enzyme Inhibitors,
pubmed-meshheading:11327591-Humans,
pubmed-meshheading:11327591-Leukocyte Elastase,
pubmed-meshheading:11327591-Models, Molecular,
pubmed-meshheading:11327591-Sensitivity and Specificity
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Design, synthesis and stability of N-acyloxymethyl- and N-aminocarbonyloxymethyl-2-azetidinones as human leukocyte elastase inhibitors.
|
| pubmed:affiliation |
INETI, Dep. Biotecnologia, Estrada das Palmeiras, Lisboa, Portugal.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|