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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-4-30
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pubmed:abstractText |
Some novel amidate prodrugs of PMEA and PMPA have been synthesised and tested in vitro for their biological activity. Compound 5 in particular showed greatly enhanced antiviral potency compared with the parent nucleotide analogue. In vitro enzymatic studies and structure-activity relationships indicate that the degradation mechanism of such prodrugs may be the same as that described for the phosphoramidate triesters of nucleotide analogues.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenine,
http://linkedlifedata.com/resource/pubmed/chemical/Alanine,
http://linkedlifedata.com/resource/pubmed/chemical/Amides,
http://linkedlifedata.com/resource/pubmed/chemical/Antiviral Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Esterases,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleotides,
http://linkedlifedata.com/resource/pubmed/chemical/Organophosphorus Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphonic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Prodrugs,
http://linkedlifedata.com/resource/pubmed/chemical/adefovir,
http://linkedlifedata.com/resource/pubmed/chemical/phosphoramidic acid,
http://linkedlifedata.com/resource/pubmed/chemical/tenofovir
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1053-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11327587-Adenine,
pubmed-meshheading:11327587-Alanine,
pubmed-meshheading:11327587-Amides,
pubmed-meshheading:11327587-Antiviral Agents,
pubmed-meshheading:11327587-Drug Stability,
pubmed-meshheading:11327587-Esterases,
pubmed-meshheading:11327587-Humans,
pubmed-meshheading:11327587-Nucleotides,
pubmed-meshheading:11327587-Organophosphorus Compounds,
pubmed-meshheading:11327587-Phosphonic Acids,
pubmed-meshheading:11327587-Phosphoric Acids,
pubmed-meshheading:11327587-Prodrugs,
pubmed-meshheading:11327587-Retroviridae,
pubmed-meshheading:11327587-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
Synthesis and evaluation of novel amidate prodrugs of PMEA and PMPA.
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pubmed:affiliation |
Welsh School of Pharmacy, Cardiff University, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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