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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-4-30
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pubmed:abstractText |
A series of arylhydantoin derivatives modeled after the antiandrogen RU 58841 was generated to identify potential candidates for development as androgen receptor (AR) radioligands. Side-chain modified derivatives of RU 58841, suitable for labeling with either carbon-11 or radiohalogens (fluorine-18, iodine-123), were synthesized and tested for their AR binding affinities. The N-(iodopropenyl) derivative 13 (Ki = 13 nM) is a potential candidate for development as a radioiodinated AR ligand.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1045-7
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11327585-Androgen Antagonists,
pubmed-meshheading:11327585-Animals,
pubmed-meshheading:11327585-Binding Sites,
pubmed-meshheading:11327585-Carbon Isotopes,
pubmed-meshheading:11327585-Fluorine,
pubmed-meshheading:11327585-Hydantoins,
pubmed-meshheading:11327585-Imidazoles,
pubmed-meshheading:11327585-Nitriles,
pubmed-meshheading:11327585-Radioligand Assay,
pubmed-meshheading:11327585-Rats,
pubmed-meshheading:11327585-Receptors, Androgen,
pubmed-meshheading:11327585-Structure-Activity Relationship
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pubmed:year |
2001
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pubmed:articleTitle |
Synthesis and structure-activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands.
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pubmed:affiliation |
Department of Radiology, The University of Michigan Medical School, Ann Arhor 48109-0552, USA. mvandort@umich.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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