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11327580
Source:
http://linkedlifedata.com/resource/pubmed/id/11327580
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rdf:type
pubmed:Citation
lifeskim:mentions
umls-concept:C0205314
,
umls-concept:C0456387
,
umls-concept:C0597298
,
umls-concept:C0679622
,
umls-concept:C1514721
,
umls-concept:C2757030
pubmed:issue
8
pubmed:dateCreated
2001-4-30
pubmed:abstractText
3-Phenyl-3.4-dihydro-1-isoquinolinamine is a weak inhibitor of iNOS and nNOS. Structural variation of 5a results in inhibitors with a range of potency and selectivity for the NOS enzymes, including a potent and very selective iNOS inhibitor 5j.
pubmed:language
eng
pubmed:journal
http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset
IM
pubmed:chemical
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors
,
http://linkedlifedata.com/resource/pubmed/chemical/Isoquinolines
,
http://linkedlifedata.com/resource/pubmed/chemical/NOS1 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/NOS2 protein, human
,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase
,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type I
,
http://linkedlifedata.com/resource/pubmed/chemical/Nitric Oxide Synthase Type II
,
http://linkedlifedata.com/resource/pubmed/chemical/Nos1 protein, rat
,
http://linkedlifedata.com/resource/pubmed/chemical/Nos2 protein, rat
,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Isoforms
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0960-894X
pubmed:author
pubmed-author:BeatonHH
,
pubmed-author:HamleyPP
,
pubmed-author:NichollsD JDJ
,
pubmed-author:TinkerA CAC
,
pubmed-author:WallaceA VAV
pubmed:issnType
Print
pubmed:day
23
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1023-6
pubmed:dateRevised
2011-10-27
pubmed:meshHeading
pubmed-meshheading:11327580-Animals
,
pubmed-meshheading:11327580-Cells, Cultured
,
pubmed-meshheading:11327580-Cerebellum
,
pubmed-meshheading:11327580-Enzyme Inhibitors
,
pubmed-meshheading:11327580-Humans
,
pubmed-meshheading:11327580-Inhibitory Concentration 50
,
pubmed-meshheading:11327580-Isoquinolines
,
pubmed-meshheading:11327580-Nitric Oxide Synthase
,
pubmed-meshheading:11327580-Nitric Oxide Synthase Type I
,
pubmed-meshheading:11327580-Nitric Oxide Synthase Type II
,
pubmed-meshheading:11327580-Protein Isoforms
,
pubmed-meshheading:11327580-Rats
,
pubmed-meshheading:11327580-Sensitivity and Specificity
pubmed:year
2001
pubmed:articleTitle
3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.
pubmed:affiliation
Department of Medicinal Chemistry, AstraZeneca R&D Charnwood, Loughborough, UK.
pubmed:publicationType
Journal Article