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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2001-4-30
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pubmed:abstractText |
The application of the oxathiaphospholane approach for the stereocontrolled synthesis of LNA dinucleoside phosphorothioate is described. The reaction of ring opening condensation proceeds in CH3CN solution in high yield and with over 96% stereoselectivity. One of diastereomers of LNA dinucleoside phosphorothioate (presumably R(P)) was found to be readily digested by svPDE.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
23
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1001-3
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11327575-Chromatography, High Pressure Liquid,
pubmed-meshheading:11327575-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11327575-Nucleic Acid Conformation,
pubmed-meshheading:11327575-Nucleotides,
pubmed-meshheading:11327575-Oligonucleotides,
pubmed-meshheading:11327575-Phosphates,
pubmed-meshheading:11327575-Phosphodiesterase I,
pubmed-meshheading:11327575-Phosphoric Diester Hydrolases,
pubmed-meshheading:11327575-Ribose,
pubmed-meshheading:11327575-Stereoisomerism
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pubmed:year |
2001
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pubmed:articleTitle |
Stereocontrolled synthesis of LNA dinucleoside phosphorothioate by the oxathiaphospholane approach.
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pubmed:affiliation |
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lód?.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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