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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2001-4-30
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pubmed:abstractText |
Platelet-derived growth factor (PDGF-BB) has been shown to enhance periodontal regeneration. Principles of guided tissue regeneration dictate that one of the goals of therapy is to modulate the wound healing processes to favor repopulation of the wound with cells derived from the periodontal ligament rather than from the gingival tissues. Using an in vitro wound model, gingival fibroblasts (GF) have been shown to fill a wound space significantly faster than periodontal ligament cells (PDL). There are no data reported directly comparing the response of these 2 cell types to PDGF-BB within such a wound model. Therefore, the aims of this research were: 1) to characterize both the proliferative and wound fill (WF) effects of PDGF-BB within an in vitro model and 2) to compare specific growth factor effects between GF and PDL.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
D
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-3492
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
72
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
331-40
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11327060-Blood,
pubmed-meshheading:11327060-Bromodeoxyuridine,
pubmed-meshheading:11327060-Cell Count,
pubmed-meshheading:11327060-Cell Division,
pubmed-meshheading:11327060-Cell Movement,
pubmed-meshheading:11327060-Cell Nucleus,
pubmed-meshheading:11327060-Cells, Cultured,
pubmed-meshheading:11327060-Coloring Agents,
pubmed-meshheading:11327060-Culture Media,
pubmed-meshheading:11327060-Cytoplasm,
pubmed-meshheading:11327060-DNA,
pubmed-meshheading:11327060-Fibroblasts,
pubmed-meshheading:11327060-Gingiva,
pubmed-meshheading:11327060-Humans,
pubmed-meshheading:11327060-Image Processing, Computer-Assisted,
pubmed-meshheading:11327060-Periodontal Ligament,
pubmed-meshheading:11327060-Platelet-Derived Growth Factor,
pubmed-meshheading:11327060-Recombinant Proteins,
pubmed-meshheading:11327060-Regeneration,
pubmed-meshheading:11327060-Statistics as Topic,
pubmed-meshheading:11327060-Time Factors,
pubmed-meshheading:11327060-Wound Healing
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pubmed:year |
2001
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pubmed:articleTitle |
The effects of platelet-derived growth factor-BB on periodontal cells in an in vitro wound model.
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pubmed:affiliation |
Department of Periodontics, Wilford Hall Medical Center, Lackland AFB, San Antonio, TX 78229, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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