Source:http://linkedlifedata.com/resource/pubmed/id/11326655
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6D
|
| pubmed:dateCreated |
2001-4-30
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| pubmed:abstractText |
Within a few weeks, if therapy of the hormone sensitive, advanced prostate cancer (PCa) is sufficient, there will be a PSA-decrease to testify to the regression of the PCa. Free-PSA (f-PSA) is used for the differential diagnosis of the PCa. Values under 25% f-PSA in proportion to complete-PSA show the possibility of the existence of a Pca. The aim of the work was to study the behavior of f-PSA under hormonal ablation. Initial PSA and f-PSA was examined (RIA) in 76 patients (average age = 72.8 yrs. old) with advanced PCa. (metastases) proven by bone scintigraphy and/or computed tomography. During hormonal therapy (LHRH-agonists) monthly PSA and f-PSA abundance were examined. The percent amount of f-PSA was calculated and documented for at least 6 months. The initial PSA-values were 43.6 +/- 17.3, the f-PSA were 13.4% +/- 8.9. Under antihormonal therapy PSA decreased (while f-PSA increased) and after a period of 1 month the values were 27.4 +/- 14.9 (17.4% +/- 12.3), after 3 months 18.1 +/- 11.3 (24.5% +/- 9.9), after 6 months 7.9 +/- 6.8 (26.1 +/- 10.6). During the 6 months of hormonal ablation PSA-values continuously declined, while, after the first 3 months, f-PSA-values showed a behavior similar to benign hyperplasia of prostate. The therapeutic efficiency of the antihormonal therapy is clearly shown through f-PSA and PSA. There are no timely advantages between the two markers. Further investigations will show whether hormone insensitive PCa can be recognized quicker through f-PSA than from an increase in PSA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:issn |
0250-7005
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
20
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
4993-4
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| pubmed:dateRevised |
2006-11-15
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| pubmed:meshHeading |
pubmed-meshheading:11326655-Adult,
pubmed-meshheading:11326655-Aged,
pubmed-meshheading:11326655-Aged, 80 and over,
pubmed-meshheading:11326655-Gonadotropin-Releasing Hormone,
pubmed-meshheading:11326655-Humans,
pubmed-meshheading:11326655-Male,
pubmed-meshheading:11326655-Middle Aged,
pubmed-meshheading:11326655-Prostate-Specific Antigen,
pubmed-meshheading:11326655-Prostatic Neoplasms
|
| pubmed:articleTitle |
The behavior of prostate specific antigen (PSA) and free-PSA (f-PSA) under antihormonal therapy.
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| pubmed:affiliation |
Urological Clinic, Reinhard-Nieter-Hospital, Friedrich-Paffrath-Str. 100, 26389 Wilhelmshaven, Germany.
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| pubmed:publicationType |
Journal Article
|