Historically, the prostate was evaluated for cancer by simple digital rectal examination, and biopsy to obtain a tissue diagnosis of cancer was performed blindly. The advent of ultrasound technology offered a new way to evaluate the prostate, and biopsy techniques were soon developed to incorporate ultrasound guidance.
Department of Urology and Comprehensive Cancer Center, Wake Forest University Baptist Medical Center, Medical Center Blvd., Winston-Salem, NC 27157-1094, USA.
