| pubmed-article:11325484 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11325484 | lifeskim:mentions | umls-concept:C0007131 | lld:lifeskim |
| pubmed-article:11325484 | lifeskim:mentions | umls-concept:C0348026 | lld:lifeskim |
| pubmed-article:11325484 | lifeskim:mentions | umls-concept:C0075091 | lld:lifeskim |
| pubmed-article:11325484 | lifeskim:mentions | umls-concept:C0237881 | lld:lifeskim |
| pubmed-article:11325484 | lifeskim:mentions | umls-concept:C0220901 | lld:lifeskim |
| pubmed-article:11325484 | lifeskim:mentions | umls-concept:C0750502 | lld:lifeskim |
| pubmed-article:11325484 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11325484 | pubmed:dateCreated | 2001-4-30 | lld:pubmed |
| pubmed-article:11325484 | pubmed:abstractText | Squamous cell carcinoma antigen (SCC-Ag) is a glycoprotein secreted by non-small cell lung tumours (NSCLC). This study investigated the diagnostic and prognostic significance of SCC-Ag in NSCLC. Receiver operating characteristic (ROC) curve analysis was used to test the diagnostic performance of the SCC-Ag and determine the optimal threshold value in a group of 100 NSCLC patients undergoing surgery and 50 age matched healthy controls. This threshold was then prospectively validated in a group of 53 patients and 49 healthy controls. The prognostic significance of the preoperative SCC-Ag level and its postoperative decrease were tested using univariate and multivariate proportional hazard models. The area under the ROC curve was 0.71+/-0.04, and the best cutoff value was 1.4 ng/ml. This discriminated patients in the validation group, with a sensitivity of 0.55 and a specificity of 1.0. The hazard ratio was 0.144 (95% CI 0.074-0.281) for the postoperative decrease in the SCC Ag, and 5.823 (3.299-10.278) for the preoperative SCC Ag level. Multivariate analysis revealed that only disease stage and patients' age are strong prognostic factors for survival. In conclusion, the SCC-Ag serum level has moderate diagnostic role in NSCLC. Both the preoperative SCC-Ag level and its postoperative decrease have prognostic significance, yet inferior to the disease stage and the patient's age. | lld:pubmed |
| pubmed-article:11325484 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11325484 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11325484 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11325484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11325484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11325484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11325484 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11325484 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11325484 | pubmed:month | May | lld:pubmed |
| pubmed-article:11325484 | pubmed:issn | 0169-5002 | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:RoussosCC | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:KittasCC | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:SotiropoulosA... | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:GorgoulisVV | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:ZakynthinosSS | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:PapirisSS | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:Vassilakopoul... | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:TroupisTT | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:ZacharatosPP | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:KatsaounouPP | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:ParthenisDD | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:NoussiaOO | lld:pubmed |
| pubmed-article:11325484 | pubmed:author | pubmed-author:TroupisGG | lld:pubmed |
| pubmed-article:11325484 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11325484 | pubmed:volume | 32 | lld:pubmed |
| pubmed-article:11325484 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11325484 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11325484 | pubmed:pagination | 137-44 | lld:pubmed |
| pubmed-article:11325484 | pubmed:dateRevised | 2004-11-17 | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:meshHeading | pubmed-meshheading:11325484... | lld:pubmed |
| pubmed-article:11325484 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11325484 | pubmed:articleTitle | Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer. | lld:pubmed |
| pubmed-article:11325484 | pubmed:affiliation | Department of Critical Care and Pulmonary Services, Evangelismos Hospital, University of Athens Medical School, Athens, Greece. | lld:pubmed |
| pubmed-article:11325484 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11325484 | pubmed:publicationType | Validation Studies | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11325484 | lld:pubmed |
