Source:http://linkedlifedata.com/resource/pubmed/id/11325484
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2001-4-30
|
| pubmed:abstractText |
Squamous cell carcinoma antigen (SCC-Ag) is a glycoprotein secreted by non-small cell lung tumours (NSCLC). This study investigated the diagnostic and prognostic significance of SCC-Ag in NSCLC. Receiver operating characteristic (ROC) curve analysis was used to test the diagnostic performance of the SCC-Ag and determine the optimal threshold value in a group of 100 NSCLC patients undergoing surgery and 50 age matched healthy controls. This threshold was then prospectively validated in a group of 53 patients and 49 healthy controls. The prognostic significance of the preoperative SCC-Ag level and its postoperative decrease were tested using univariate and multivariate proportional hazard models. The area under the ROC curve was 0.71+/-0.04, and the best cutoff value was 1.4 ng/ml. This discriminated patients in the validation group, with a sensitivity of 0.55 and a specificity of 1.0. The hazard ratio was 0.144 (95% CI 0.074-0.281) for the postoperative decrease in the SCC Ag, and 5.823 (3.299-10.278) for the preoperative SCC Ag level. Multivariate analysis revealed that only disease stage and patients' age are strong prognostic factors for survival. In conclusion, the SCC-Ag serum level has moderate diagnostic role in NSCLC. Both the preoperative SCC-Ag level and its postoperative decrease have prognostic significance, yet inferior to the disease stage and the patient's age.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
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| pubmed:issn |
0169-5002
|
| pubmed:author |
pubmed-author:GorgoulisVV,
pubmed-author:KatsaounouPP,
pubmed-author:KittasCC,
pubmed-author:NoussiaOO,
pubmed-author:PapirisSS,
pubmed-author:ParthenisDD,
pubmed-author:RoussosCC,
pubmed-author:SotiropoulosAA,
pubmed-author:TroupisGG,
pubmed-author:TroupisTT,
pubmed-author:VassilakopoulosTT,
pubmed-author:ZacharatosPP,
pubmed-author:ZakynthinosSS
|
| pubmed:issnType |
Print
|
| pubmed:volume |
32
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
137-44
|
| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11325484-Adenocarcinoma,
pubmed-meshheading:11325484-Aged,
pubmed-meshheading:11325484-Antigens, Neoplasm,
pubmed-meshheading:11325484-Carcinoma, Large Cell,
pubmed-meshheading:11325484-Carcinoma, Non-Small-Cell Lung,
pubmed-meshheading:11325484-Female,
pubmed-meshheading:11325484-Humans,
pubmed-meshheading:11325484-Life Tables,
pubmed-meshheading:11325484-Lung Neoplasms,
pubmed-meshheading:11325484-Male,
pubmed-meshheading:11325484-Middle Aged,
pubmed-meshheading:11325484-Multivariate Analysis,
pubmed-meshheading:11325484-Prognosis,
pubmed-meshheading:11325484-Proportional Hazards Models,
pubmed-meshheading:11325484-Prospective Studies,
pubmed-meshheading:11325484-ROC Curve,
pubmed-meshheading:11325484-Sensitivity and Specificity,
pubmed-meshheading:11325484-Serpins,
pubmed-meshheading:11325484-Survival Analysis,
pubmed-meshheading:11325484-Tumor Markers, Biological
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Diagnostic and prognostic significance of squamous cell carcinoma antigen in non-small cell lung cancer.
|
| pubmed:affiliation |
Department of Critical Care and Pulmonary Services, Evangelismos Hospital, University of Athens Medical School, Athens, Greece.
|
| pubmed:publicationType |
Journal Article,
Validation Studies
|