Linked Life Data

11325392

Source:http://linkedlifedata.com/resource/pubmed/id/11325392

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2001-4-30
pubmed:abstractText
In many laboratory studies, a subpopulation of subjects fails to exhibit the response under investigation during the period of observation. For example, within any population of male rats, there is significant variation in the expression of sexual behavior in the presence of a receptive female. Some males may never display the full sequence of behaviors leading to ejaculation within the typical time frame of the testing session, with the resulting lack of behavioral response presenting problems in the analysis of the data. Conventional strategies range from screening such males from the study or dropping them from the analysis to constructing new variables based on estimates from existing parameters or increasing the length of the test session to capture sexual responses in a greater portion of males. Herein, we present an alternative strategy for analyzing data where outcomes are absent due to the limited observation period. Survival regression analysis enables inclusion of all subjects in the analysis whether or not they have shown the behavior of interest. Use of such a strategy not only has potential to reveal new results but also guards against bias from excluding nonresponders from the study or dropping more males from one experimental condition than another. Furthermore, this procedure can be helpful in generating the conditional probability (increase, decrease, or constant) of the response with the passage of time based on the hazard function and in estimating parameters for establishing an optimal behavioral test length for future studies.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0091-3057
pubmed:author
pubmed:issnType
Print
pubmed:volume
68
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
403-9
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Testing and analytical procedures for laboratory studies involving nonresponders during a limited observation period: an illustration using male sexual behavior in rats.
pubmed:affiliation
Department of Psychology, Valparaiso University, Valparaiso, IN 46383, USA. david.rowland@valpo.edu
pubmed:publicationType
Journal Article