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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-4-27
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pubmed:abstractText |
Pre-T cell antigen receptor (pre-TCR) signaling plays a crucial role in the development of immature T cells. Although certain aspects of proximal pre-TCR signaling have been studied, the intermediate signal transducers and the distal transcription modulators have been poorly characterized. We report here a correlation between pre-TCR signaling and a biphasic rise in the cytosolic Ca2+ concentration. In addition, we show that constitutive pre-TCR signaling is associated with an increased rate of Ca2+ influx through store-operated plasma membrane Ca2+ channels. We show also that the biphasic nature of the observed pre-TCR-induced rise in cytosolic Ca2+ differentially modulates the activities of the transcription factors NF-kappaB and NFAT in developing T cells.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/GEM protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Gem protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Immediate-Early Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Monomeric GTP-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/NFATC Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Rag2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/V(D)J recombination activating...,
http://linkedlifedata.com/resource/pubmed/chemical/pre-T cell receptor alpha
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1529-2908
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
403-9
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:11323693-Animals,
pubmed-meshheading:11323693-Calcium Signaling,
pubmed-meshheading:11323693-Cell Differentiation,
pubmed-meshheading:11323693-DNA-Binding Proteins,
pubmed-meshheading:11323693-Hematopoietic Stem Cells,
pubmed-meshheading:11323693-Immediate-Early Proteins,
pubmed-meshheading:11323693-Membrane Glycoproteins,
pubmed-meshheading:11323693-Mice,
pubmed-meshheading:11323693-Mice, Inbred BALB C,
pubmed-meshheading:11323693-Mice, Mutant Strains,
pubmed-meshheading:11323693-Models, Genetic,
pubmed-meshheading:11323693-Monomeric GTP-Binding Proteins,
pubmed-meshheading:11323693-NF-kappa B,
pubmed-meshheading:11323693-NFATC Transcription Factors,
pubmed-meshheading:11323693-Nuclear Proteins,
pubmed-meshheading:11323693-Receptors, Antigen, T-Cell, alpha-beta,
pubmed-meshheading:11323693-Selection, Genetic,
pubmed-meshheading:11323693-Signal Transduction,
pubmed-meshheading:11323693-T-Lymphocytes,
pubmed-meshheading:11323693-Thymus Gland,
pubmed-meshheading:11323693-Transcription Factors
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pubmed:year |
2001
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pubmed:articleTitle |
Constitutive pre-TCR signaling promotes differentiation through Ca2+ mobilization and activation of NF-kappaB and NFAT.
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pubmed:affiliation |
Department of Pathology, Harvard Medical School, Dana-Farber Cancer Institute, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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