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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-4-27
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pubmed:abstractText |
OBJECTIVE AND SUMMARY BACKGROUND DATA: Tumor-specific gene therapy can be achieved if a tumor-specific promoter can be identified. In this study the authors investigated the use of the rat insulin promoter (RIP) for insulinoma-specific expression of a reporter gene. Insulinoma-specific cytotoxicity using the suicide gene thymidine kinase (tk) was studied both in vitro and in vivo. RIPtk gene therapy, delivered by a nontoxic, noninflammatory liposomal delivery system, was used in an insulinoma ICR/SCID mouse model to prevent hypoglycemic death.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-10022541,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-10519403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-1647994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-7585589,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-7860993,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-7923150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-8159705,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-8626129,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-8712678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-8800746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-9070891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-9194627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-9218757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-9219267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-9788604,
http://linkedlifedata.com/resource/pubmed/commentcorrection/11323498-9824053
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0003-4932
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
233
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
603-11
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pubmed:dateRevised |
2011-1-11
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pubmed:meshHeading |
pubmed-meshheading:11323498-Animals,
pubmed-meshheading:11323498-Antiviral Agents,
pubmed-meshheading:11323498-Disease Models, Animal,
pubmed-meshheading:11323498-Female,
pubmed-meshheading:11323498-Ganciclovir,
pubmed-meshheading:11323498-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:11323498-Gene Therapy,
pubmed-meshheading:11323498-Insulinoma,
pubmed-meshheading:11323498-Lac Operon,
pubmed-meshheading:11323498-Mice,
pubmed-meshheading:11323498-Mice, Inbred ICR,
pubmed-meshheading:11323498-Mice, SCID,
pubmed-meshheading:11323498-Neoplasm Proteins,
pubmed-meshheading:11323498-Nuclear Proteins,
pubmed-meshheading:11323498-Pancreatic Neoplasms,
pubmed-meshheading:11323498-Transcription, Genetic,
pubmed-meshheading:11323498-Tumor Cells, Cultured
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pubmed:year |
2001
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pubmed:articleTitle |
Insulinoma-induced hypoglycemic death in mice is prevented with beta cell-specific gene therapy.
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pubmed:affiliation |
Departments of Molecular Biology and Center for Gene Therapy, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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