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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2001-4-27
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pubmed:abstractText |
The backbone dynamics of the channel-forming peptide antibiotic zervamicin IIB (Zrv-IIB) in methanol were studied by 15N nuclear magnetic resonance relaxation measurements at 11.7, 14.1 and 18.8 T magnetic fields. The anisotropic overall rotation of the peptide was characterized based on 15N relaxation data and by hydrodynamic calculations. 'Model-free' analysis of the relaxation data showed that the peptide is fairly rigid on a sub-nanosecond time-scale. The residues from the polar side of Zrv-IIB helix are involved in micro-millisecond time-scale conformational exchange. The conformational exchange observed might indicate intramolecular processes or specific intermolecular interactions of potential relevance to Zrv-IIB ion channel formation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
20
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pubmed:volume |
495
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
52-5
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:11322946-Anisotropy,
pubmed-meshheading:11322946-Anti-Bacterial Agents,
pubmed-meshheading:11322946-Computer Simulation,
pubmed-meshheading:11322946-Ion Channels,
pubmed-meshheading:11322946-Methanol,
pubmed-meshheading:11322946-Molecular Conformation,
pubmed-meshheading:11322946-Nitrogen Isotopes,
pubmed-meshheading:11322946-Nuclear Magnetic Resonance, Biomolecular,
pubmed-meshheading:11322946-Peptaibols,
pubmed-meshheading:11322946-Peptides,
pubmed-meshheading:11322946-Rotation
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pubmed:year |
2001
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pubmed:articleTitle |
Backbone dynamics of the channel-forming antibiotic zervamicin IIB studied by 15N NMR relaxation.
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pubmed:affiliation |
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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