Linked Life Data

11322343

Source:http://linkedlifedata.com/resource/pubmed/id/11322343

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-4-26
pubmed:abstractText
11-day chick embryo skin fibroblasts administered in vitro with colchicine or cytochalasin B, have been investigated for collagen synthesis and secretion. The cytoskeleton, examined by confocal laser scanning immunofluorescence microscope, exibited in colchicine treated cells a clear loss of microtubules, in cytochalasin B treated cells a diffuse staining and patches of intracellular fluorescence caused by actin disassembly. Cytochalasin B treatment decreased endocellular type I collagen synthesis and the total uptake of 3H-proline, while enhanced collagen secretion. Colchicine did not interfere with the collagen secretion and the label uptake, whereas it increased endocellular collagen synthesis. In addition, both drugs induced an increase of the alpha2:alpha1 ratio of collagen chains. The results obtained suggest that the cytoskeleton controls not only the morphological organization of cell components, but also the organization of biochemical processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
1122-6714
pubmed:author
pubmed:issnType
Print
pubmed:volume
100 Suppl 1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
65-74
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1995
pubmed:articleTitle
Involvement of the cytoskeleton in regulation of collagen synthesis and secretion.
pubmed:affiliation
Istituto di Istologia ed Embriologia Generale-Università di Ferrara, Italia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't