Linked Life Data

11322014

Source:http://linkedlifedata.com/resource/pubmed/id/11322014

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-4-26
pubmed:abstractText
Ursodeoxycholic acid is a protective agent against liver toxicity caused by some drugs. In the present pilot study, we assessed the effect of this bile acid on tacrine-induced hepatotoxicity. Fourteen patients with a diagnosis of Alzheimer's disease received tacrine and ursodeoxycholic acid (13 mg/kg/day) for 105 days. Serum ALAT was the main evaluation criterion. Serum levels of ALAT were compared with those of 100 patients who had been treated with tacrine in the same centre. In patients receiving ursodeoxycholic acid, ALAT serum levels were normal in 93 per cent of cases vs. 69 per cent in control patients and moderate hepatotoxicity (ULN < ALAT < 3 ULN) did not occur while it was present in 25 per cent of controls (p = 0.036). In contrast, the percentage of patients with ALAT > 3 ULN was similar in the two groups (7 per cent vs. 6 per cent). These present findings suggest that UDC could prevent moderate tacrine-induced hepatotoxicity. These results should be confirmed in a controlled therapeutical trial.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0040-5957
pubmed:author
pubmed:issnType
Print
pubmed:volume
56
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
29-34
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:articleTitle
[Ursodeoxycholic acid and prevention of tacrine-induced hepatotoxicity: a pilot study].
pubmed:affiliation
INSERM, 46 Bd de la Gaye, Marseille, France.
pubmed:publicationType
Journal Article, Clinical Trial, English Abstract, Research Support, Non-U.S. Gov't