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PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2001-4-26
pubmed:abstractText
To evaluate the prevalence of extended-spectrum beta-lactamase (ESBL)-producing strains among species of Enterobacteriaceae, a microdilution susceptibility test was performed with strains of Klebsiella pneumoniae, Escherichia coli, Proteus mirabilis, and Salmonella species that were isolated as part of the SENTRY project. The highest percentage of ESBL phenotype (defined as a minimum inhibitory concentration [MIC] > or =2 microg/mL for ceftazidime, ceftriaxone, or aztreonam) was detected among K. pneumoniae strains from Latin America (45%), followed by those from the Western Pacific region (25%), Europe (23%), the United States (8%), and Canada (5%). P. mirabilis and E. coli strains for which MICs of extended-spectrum cephalosporins or monobactams were elevated also were more prominent in Latin America. Testing with ceftazidime revealed more isolates with elevated MICs than did testing with ceftriaxone or aztreonam. ESBL strains showed high levels of co-resistance to aminoglycosides, tetracycline, trimethoprim-sulfamethoxazole, and ciprofloxacin. Imipenem remains highly effective against ESBL strains. Organisms expressing an ESBL are widely distributed worldwide, although prevalence rates are significantly higher in certain geographic regions.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1058-4838
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
32 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
S94-103
pubmed:meshHeading
pubmed-meshheading:11320450-Aztreonam, pubmed-meshheading:11320450-Ceftazidime, pubmed-meshheading:11320450-Ceftriaxone, pubmed-meshheading:11320450-Cephalosporins, pubmed-meshheading:11320450-Drug Resistance, Multiple, pubmed-meshheading:11320450-Electrophoresis, Gel, Pulsed-Field, pubmed-meshheading:11320450-Enterobacteriaceae, pubmed-meshheading:11320450-Escherichia coli, pubmed-meshheading:11320450-Europe, pubmed-meshheading:11320450-Far East, pubmed-meshheading:11320450-Klebsiella pneumoniae, pubmed-meshheading:11320450-Latin America, pubmed-meshheading:11320450-Microbial Sensitivity Tests, pubmed-meshheading:11320450-North America, pubmed-meshheading:11320450-Phenotype, pubmed-meshheading:11320450-Proteus mirabilis, pubmed-meshheading:11320450-Ribotyping, pubmed-meshheading:11320450-Salmonella, pubmed-meshheading:11320450-beta-Lactam Resistance, pubmed-meshheading:11320450-beta-Lactamases
pubmed:year
2001
pubmed:articleTitle
Variations in the prevalence of strains expressing an extended-spectrum beta-lactamase phenotype and characterization of isolates from Europe, the Americas, and the Western Pacific region.
pubmed:affiliation
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City, IA 52242, USA. patricia-winokur@uiowa.edu
pubmed:publicationType
Journal Article