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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-4-25
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pubmed:abstractText |
Basic fibroblast growth factor (bFGF) is an angiogenic growth factor that is involved in renal growth and the pathogenesis of renal diseases. We have detected high levels of bFGF accumulated in the kidney of HIV-transgenic mice and in children with HIV-associated renal diseases and the hemolytic uremic syndrome (HUS). However, the mechanism modulating the activity of bFGF under these circumstances is poorly understood. We carried out experiments to determine whether a secreted binding protein (FGF-BP) that modulates the activity of bFGF during the process of tumor growth was expressed in pediatric kidneys and to define whether the expression of FGF-BP was altered in pediatric renal diseases associated with high levels of bFGF.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA Primers,
http://linkedlifedata.com/resource/pubmed/chemical/FGFBP1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Fgfbp1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Fibroblast Growth Factor 2,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Thymidine
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0085-2538
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1717-28
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:11318942-AIDS-Associated Nephropathy,
pubmed-meshheading:11318942-Animals,
pubmed-meshheading:11318942-Base Sequence,
pubmed-meshheading:11318942-Carrier Proteins,
pubmed-meshheading:11318942-Case-Control Studies,
pubmed-meshheading:11318942-Cells, Cultured,
pubmed-meshheading:11318942-Child,
pubmed-meshheading:11318942-DNA Primers,
pubmed-meshheading:11318942-Fetus,
pubmed-meshheading:11318942-Fibroblast Growth Factor 2,
pubmed-meshheading:11318942-Hemolytic-Uremic Syndrome,
pubmed-meshheading:11318942-Humans,
pubmed-meshheading:11318942-Immunohistochemistry,
pubmed-meshheading:11318942-In Situ Hybridization,
pubmed-meshheading:11318942-Kidney Diseases,
pubmed-meshheading:11318942-Kidney Tubules, Proximal,
pubmed-meshheading:11318942-Mice,
pubmed-meshheading:11318942-Models, Biological,
pubmed-meshheading:11318942-RNA, Messenger,
pubmed-meshheading:11318942-Recombinant Proteins,
pubmed-meshheading:11318942-Thymidine,
pubmed-meshheading:11318942-Up-Regulation
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pubmed:year |
2001
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pubmed:articleTitle |
Up-regulation of a fibroblast growth factor binding protein in children with renal diseases.
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pubmed:affiliation |
Children's Research Institute, Research Center for Molecular Physiology, Children's National Medical Center, Washington DC 20010, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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