Linked Life Data

11315715

Source:http://linkedlifedata.com/resource/pubmed/id/11315715

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2001-4-23
pubmed:abstractText
We report the case history of a woman with a germ line mutation in the TP53 gene who developed 17 separate primary tumours. The incidence of new tumours rose steeply after adjuvant tamoxifen treatment for breast cancer and adjuvant vaginal vault radiotherapy for endometrial cancer. This increase could be due to cumulative genetic damage from environmental agents and the fact that the patient lived to the relatively late age of 60 years, or to a high inherent deleterious somatic mutation rate, which could represent the inability of cells from patients with TP53 mutations to repair therapy-induced genetic damage.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0936-6555
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
300-4
pubmed:dateRevised
2008-3-10
pubmed:meshHeading
pubmed:year
2000
pubmed:articleTitle
A patient with 17 primary tumours and a germ line mutation in TP53: tumour induction by adjuvant therapy?
pubmed:affiliation
Royal Marsden NHS Trust, Sutton, UK.
pubmed:publicationType
Journal Article, Review, Case Reports, Research Support, Non-U.S. Gov't