Linked Life Data

11313954

Source:http://linkedlifedata.com/resource/pubmed/id/11313954

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2001-4-23
pubmed:abstractText
Resistance to apoptosis and ability to promote angiogenesis are integral features of the metastatic phenotype. Human gene CC3 is a metastasis suppressor for variant small cell lung carcinoma and a mouse melanoma in vivo. We have shown previously that metastasis-suppressing function of CC3 might be due at least in part to the ability of CC3 protein to predispose tumor cells to apoptosis. Here we demonstrate that CC3 has a previously unidentified effect on the ability of tumor cells to induce angiogenesis in vitro. Expression of CC3 in three different tumor cell lines significantly diminished their angiogenic character as manifested in the in vitro proliferation and migration assays with endothelial cells of both macro- and microvascular origin. Expression of CC3 induced changes in RNA levels of several angiogenic modulators consistent with the overall reduction in angiogenic properties. These results indicate that expression of CC3 has a dual effect on phenotype of tumor cells ultimately inhibiting their metastatic potential.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0950-9232
pubmed:author
pubmed:issnType
Print
pubmed:day
11
pubmed:volume
20
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
270-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed-meshheading:11313954-Acetyltransferases, pubmed-meshheading:11313954-Carcinoma, Small Cell, pubmed-meshheading:11313954-Cell Line, pubmed-meshheading:11313954-Cell Movement, pubmed-meshheading:11313954-Culture Media, Conditioned, pubmed-meshheading:11313954-Endothelial Growth Factors, pubmed-meshheading:11313954-Endothelium, Vascular, pubmed-meshheading:11313954-Fibroblast Growth Factor 2, pubmed-meshheading:11313954-Lung Neoplasms, pubmed-meshheading:11313954-Lymphokines, pubmed-meshheading:11313954-Neovascularization, Pathologic, pubmed-meshheading:11313954-Transcription Factors, pubmed-meshheading:11313954-Transforming Growth Factor beta, pubmed-meshheading:11313954-Tumor Cells, Cultured, pubmed-meshheading:11313954-Vascular Endothelial Growth Factor A, pubmed-meshheading:11313954-Vascular Endothelial Growth Factors
pubmed:year
2001
pubmed:articleTitle
Metastasis suppressor CC3 inhibits angiogenic properties of tumor cells in vitro.
pubmed:affiliation
Cancer Research Institute, University of California San Francisco, 94143-0128, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't