Source:http://linkedlifedata.com/resource/pubmed/id/11313670
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-4-23
|
| pubmed:abstractText |
We investigated the impact of the most commonly used preparative regimens on the outcome of 395 patients with diffuse large cell lymphoma (DLCL), consecutively reported to the registry of the Spanish GEL/TAMO. Among them, 139 (35%) were autografted in 1st CR, 86 (22%) in 2nd/3rd CR, 124 (31%) had chemosensitive disease and 46 (12%) had chemoresistant disease. Conditioning consisted of chemotherapy-only in 348 patients (BEAM, 164; BEAC, 145; and CBV, 39) and radiochemotherapy with CY and TBI in 47. Median times to granulocyte, platelet recovery and to discharge were significantly shorter in the chemotherapy-only group. Early transplant-related mortality was significantly higher when using CY-TBI. After a median follow-up of 28 months, overall survival (OS) at 8 years of patients conditioned with BEAM or BEAC (58% (95% CI 50-66%)) was more favorable than with CBV (40% (95% CI 24-56%)), and significantly better than with CY-TBI (31% (95% CI 18-44%)). Multivariate analysis revealed that patients conditioned with chemotherapy-only regimens had improved OS, disease-free (DFS) and relapse-free survival (RFS) when compared to those conditioned with CY-TBI. Status at transplant was also a powerful prognostic indicator. We conclude that preparative regimens consisting of chemotherapy-only seem more efficacious than CY-TBI as conditioning for DLCL, because of faster engraftment and greater anti-lymphoma effect, as indicated by improved OS, DFS and RFS.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0268-3369
|
| pubmed:author |
pubmed-author:ArranzRR,
pubmed-author:CaballeroM DMD,
pubmed-author:CondeEE,
pubmed-author:GEL/TAMO Spanish Cooperative Group,
pubmed-author:GandarillasMM,
pubmed-author:García-CondeJJ,
pubmed-author:García-LarañaJJ,
pubmed-author:GarcíaJ CJC,
pubmed-author:GrañenaAA,
pubmed-author:López-GuillermoAA,
pubmed-author:LahuertaJ JJJ,
pubmed-author:LeónAA,
pubmed-author:MarínJJ,
pubmed-author:SalarAA,
pubmed-author:SanzM AMA,
pubmed-author:SierraJJ,
pubmed-author:ZuazuJJ
|
| pubmed:issnType |
Print
|
| pubmed:volume |
27
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
405-12
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:11313670-Adolescent,
pubmed-meshheading:11313670-Adult,
pubmed-meshheading:11313670-Aged,
pubmed-meshheading:11313670-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:11313670-Cause of Death,
pubmed-meshheading:11313670-Child,
pubmed-meshheading:11313670-Child, Preschool,
pubmed-meshheading:11313670-Female,
pubmed-meshheading:11313670-Graft Survival,
pubmed-meshheading:11313670-Hematopoiesis,
pubmed-meshheading:11313670-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:11313670-Humans,
pubmed-meshheading:11313670-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:11313670-Lymphoma, Non-Hodgkin,
pubmed-meshheading:11313670-Male,
pubmed-meshheading:11313670-Middle Aged,
pubmed-meshheading:11313670-Prospective Studies,
pubmed-meshheading:11313670-Radiotherapy, Adjuvant,
pubmed-meshheading:11313670-Registries,
pubmed-meshheading:11313670-Spain,
pubmed-meshheading:11313670-Transplantation, Autologous,
pubmed-meshheading:11313670-Transplantation Conditioning,
pubmed-meshheading:11313670-Treatment Outcome
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Autologous stem cell transplantation for clinically aggressive non-Hodgkin's lymphoma: the role of preparative regimens.
|
| pubmed:affiliation |
Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Multicenter Study
|