Linked Life Data

11313449

Source:http://linkedlifedata.com/resource/pubmed/id/11313449

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
Pt 3
pubmed:dateCreated
2001-4-23
pubmed:abstractText
The anterior cingulate cortex (ACC) is important for processing different types of information, including sensory inputs. In the present study on anaesthetised rats, we recorded in vivo sensory responses of the ACC to peripheral electrical shocks. Peripheral electrical stimulation at high intensities sufficient to activate nociceptive sensory fibres elicited EPSPs within the ACC. Digit amputation caused long-lasting potentiation of ACC responses to peripheral electrical stimulation. Evoked field EPSPs remained enhanced for at least 120 min after the amputation. Because electrical shocks were delivered to the normal hindpaw, it is likely that plastic changes occur centrally in the spinal cord or the supraspinal structures following amputation. We also recorded field EPSPs of the ACC in response to focal cortical stimulation within the ACC. Like the sensory responses, field EPSPs produced by focal cortical stimulation within the ACC were potentiated after digit amputation, suggesting that long-lasting changes occurred locally within the ACC. Local blockade of peripheral activity by QX-314 at the amputated hindpaw 120 min after amputation did not significantly affect sensory responses induced within the ACC. Thus, peripheral ongoing inputs do not play an important role in maintaining potentiation within the ACC. Two pulses of hindpaw stimulation caused paired-pulse depression in the ACC. Local stimulation within the ACC also caused depression of sensory responses to hindpaw stimulation, suggesting that the population of synapses activated by local stimulation may overlap with that activated by peripheral hindpaw stimulation. Our results suggest that rapid enhancement of sensory responses can be observed in the ACC after amputation and that enhanced neuronal responses to subsequent somatosensory stimuli may contribute to phantom-limb pain.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-10230786, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-10321241, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-10529452, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-10531439, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-10647008, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-107587, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-10833558, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-13893868, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-1439826, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-1479441, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-1688165, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-1691874, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-1843843, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-2003220, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-2031570, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-3362565, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-4370936, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-6725633, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-6988765, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-7477346, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-7566144, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-7777055, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-7895011, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-7907137, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-7919934, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-8248123, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-8421494, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-8725971, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-8758953, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-8867243, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-8918874, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-9212281, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-9450741, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-9530495, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-9535984, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-9559934, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-9666072, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-9804549, http://linkedlifedata.com/resource/pubmed/commentcorrection/11313449-9804550
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3751
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
532
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
823-33
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Potentiation of sensory responses in the anterior cingulate cortex following digit amputation in the anaesthetised rat.
pubmed:affiliation
Department of Anesthesiology, Washington University Pain Center, Washington University School of Medicine, St Louis, MO 63110, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't