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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2001-4-23
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pubmed:abstractText |
Many studies indicate that gallstone susceptibility has genetic components. MDR3 is the phosphatidylcholine translocator across the hepatocyte canalicular membrane. Because phospholipids are a carrier and a solvent of cholesterol in hepatic bile, we hypothesized that a defect in the MDR3 gene could be the genetic basis for peculiar forms of cholesterol gallstone disease, in particular those associated with symptoms and cholestasis without evident common bile duct stone.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0016-5085
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
120
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1459-67
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:11313316-ATP-Binding Cassette Transporters,
pubmed-meshheading:11313316-Adolescent,
pubmed-meshheading:11313316-Adult,
pubmed-meshheading:11313316-Bile,
pubmed-meshheading:11313316-Cholelithiasis,
pubmed-meshheading:11313316-Cholesterol,
pubmed-meshheading:11313316-Female,
pubmed-meshheading:11313316-Humans,
pubmed-meshheading:11313316-Male,
pubmed-meshheading:11313316-Middle Aged,
pubmed-meshheading:11313316-P-Glycoproteins,
pubmed-meshheading:11313316-Ursodeoxycholic Acid
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pubmed:year |
2001
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pubmed:articleTitle |
MDR3 gene defect in adults with symptomatic intrahepatic and gallbladder cholesterol cholelithiasis.
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pubmed:affiliation |
Service d'Hépato-gastroentérologie, Hôpital Saint-Antoine, Assistance publique-Hôpitaux de Paris, France.
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pubmed:publicationType |
Journal Article
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