| pubmed-article:11312602 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11312602 | lifeskim:mentions | umls-concept:C0038435 | lld:lifeskim |
| pubmed-article:11312602 | lifeskim:mentions | umls-concept:C0027882 | lld:lifeskim |
| pubmed-article:11312602 | lifeskim:mentions | umls-concept:C0019564 | lld:lifeskim |
| pubmed-article:11312602 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:11312602 | lifeskim:mentions | umls-concept:C0475224 | lld:lifeskim |
| pubmed-article:11312602 | lifeskim:mentions | umls-concept:C0205225 | lld:lifeskim |
| pubmed-article:11312602 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:11312602 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11312602 | pubmed:dateCreated | 2001-4-23 | lld:pubmed |
| pubmed-article:11312602 | pubmed:abstractText | A specific interaction between the AMPA receptor subunits GluR2 and GluR3 and the fusion protein NSF has recently been identified. Disruption of this interaction by adenoviral-mediated expression of a peptide (pep2m) corresponding to the NSF-binding region of GluR2 results in a dramatic reduction in surface expression of AMPA receptors in primary hippocampal neurons. Here we report that expression of pep2m from a recently developed neuronal-specific adenoviral system gave significant neuroprotection to primary CA1-CA3 hippocampal neurons following stimulation with kainate (KA) and this was accompanied by a reduction in Ca(2+) influx. Protection was also observed following glucose deprivation and exposure to ischemic buffer in the absence of any NMDA receptor antagonists. These results provide strong evidence that AMPA receptors play a direct role in mediating postischemic neurotoxicity. | lld:pubmed |
| pubmed-article:11312602 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11312602 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312602 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11312602 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11312602 | pubmed:issn | 1044-7431 | lld:pubmed |
| pubmed-article:11312602 | pubmed:author | pubmed-author:NIEE | lld:pubmed |
| pubmed-article:11312602 | pubmed:author | pubmed-author:TanH KHK | lld:pubmed |
| pubmed-article:11312602 | pubmed:author | pubmed-author:NoelJJ | lld:pubmed |
| pubmed-article:11312602 | pubmed:author | pubmed-author:HenleyJ MJM | lld:pubmed |
| pubmed-article:11312602 | pubmed:author | pubmed-author:UneyJ BJB | lld:pubmed |
| pubmed-article:11312602 | pubmed:author | pubmed-author:RalphG SGS | lld:pubmed |
| pubmed-article:11312602 | pubmed:author | pubmed-author:BienemannAA | lld:pubmed |
| pubmed-article:11312602 | pubmed:copyrightInfo | Copyright 2001 Academic Press. | lld:pubmed |
| pubmed-article:11312602 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11312602 | pubmed:volume | 17 | lld:pubmed |
| pubmed-article:11312602 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11312602 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11312602 | pubmed:pagination | 662-70 | lld:pubmed |
| pubmed-article:11312602 | pubmed:dateRevised | 2008-12-3 | lld:pubmed |
| pubmed-article:11312602 | pubmed:meshHeading | pubmed-meshheading:11312602... | lld:pubmed |
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| pubmed-article:11312602 | pubmed:meshHeading | pubmed-meshheading:11312602... | lld:pubmed |
| pubmed-article:11312602 | pubmed:meshHeading | pubmed-meshheading:11312602... | lld:pubmed |
| pubmed-article:11312602 | pubmed:meshHeading | pubmed-meshheading:11312602... | lld:pubmed |
| pubmed-article:11312602 | pubmed:meshHeading | pubmed-meshheading:11312602... | lld:pubmed |
| pubmed-article:11312602 | pubmed:meshHeading | pubmed-meshheading:11312602... | lld:pubmed |
| pubmed-article:11312602 | pubmed:meshHeading | pubmed-meshheading:11312602... | lld:pubmed |
| pubmed-article:11312602 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11312602 | pubmed:articleTitle | Disruption of the GluR2-NSF interaction protects primary hippocampal neurons from ischemic stress. | lld:pubmed |
| pubmed-article:11312602 | pubmed:affiliation | Division of Medicine, University of Bristol, Marlborough Street, Bristol, BS2 8HW. | lld:pubmed |
| pubmed-article:11312602 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11312602 | lld:pubmed |
