Linked Life Data

11312360

Source:http://linkedlifedata.com/resource/pubmed/id/11312360

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2001-4-20
pubmed:abstractText
Porcine reproductive and respiratory syndrome (PRRS) consistently elevates the frequency of disease and mortality in young pigs. Many different secondary bacterial diseases occur in PRRS virus (PRRSV)-infected pigs. However, to date, establishing a reproducible experimental model of PRRSV infection in weaned pigs, with subsequent clinical disease following secondary bacterial challenge, has been difficult. PRRSV is frequently isolated during outbreaks from weak-born piglets affected by secondary bacterial diseases. This study was performed to investigate the potential role of intrauterine PRRSV infection on piglet susceptibility to secondary bacterial infection. PRRSV-free pregnant sows were intranasally infected at 98 days of gestation with PRRSV strain SD 23983. All piglets born to the PRRSV-infected sows were viremic. Piglets were removed from the sows at birth and deprived of colostrum. Piglets from PRRSV-infected and noninfected sows were randomly assigned to Streptococcus suis challenge or control subgroups. At 5 days of age, piglets were challenged intranasally with strain MN 87555 of S. suis type II. Total and differential leukocyte counts were performed on blood samples collected at 3 days of age. The numbers of leukocytes, lymphocytes, and monocytes were significantly reduced in the PRRSV-infected piglets. Lesions were observed in bone marrow, brain, lung, heart, spleen, lymph node, tonsil, and thymus of PRRSV-infected piglets. Thymus/body weight ratios of in utero PRRSV-infected piglets were significantly reduced compared to those of non-PRRSV-infected piglets, and thymic lesions were characterized by severe cortical depletion of thymocytes. Lesions were not observed in piglets born to PRRSV-free sows. Overall, 20 out of 22 piglets in the PRRSV-S. suis dual-infection group died within 1 week after challenge with S. suis (10 of 11 in each of two trials). This contrasts with 1 of 18 piglets in the PRRSV-infection-only group and 5 of 23 piglets in the S. suis-challenge-only group (1 of 12 in trial 1 and 4 of 11 in trial 2). No piglets died in the uninfected control groups. Most of the piglets in the PRRSV-S. suis dual-infection group developed suppurative meningitis. S. suis type II was recovered from their brains and joints. These results indicate that in utero infection by PRRSV makes piglets more susceptible to infection and disease following challenge by S. suis type II. In utero infection by PRRSV may provide a useful model to study the interaction between PRRSV and bacterial coinfections in piglets.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-10703702, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-1616976, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-1949539, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-4792015, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-7483210, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-7578444, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-7666249, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-7709569, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-7771065, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8011777, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8068760, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8135015, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8257302, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8269364, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8373860, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8517032, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8627762, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-8962629, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-9054128, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-9220619, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-9220620, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-9220621, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-9220622, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-9349308, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-9477481, http://linkedlifedata.com/resource/pubmed/commentcorrection/11312360-9798089
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-538X
pubmed:author
pubmed:issnType
Print
pubmed:volume
75
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4889-95
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
In utero infection by porcine reproductive and respiratory syndrome virus is sufficient to increase susceptibility of piglets to challenge by Streptococcus suis type II.
pubmed:affiliation
Department of Farm Animal Health and Resource Management, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't