| pubmed-article:11312329 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11312329 | lifeskim:mentions | umls-concept:C0035236 | lld:lifeskim |
| pubmed-article:11312329 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:11312329 | lifeskim:mentions | umls-concept:C0030392 | lld:lifeskim |
| pubmed-article:11312329 | lifeskim:mentions | umls-concept:C0007452 | lld:lifeskim |
| pubmed-article:11312329 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:11312329 | lifeskim:mentions | umls-concept:C0521115 | lld:lifeskim |
| pubmed-article:11312329 | lifeskim:mentions | umls-concept:C0036639 | lld:lifeskim |
| pubmed-article:11312329 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11312329 | pubmed:dateCreated | 2001-4-20 | lld:pubmed |
| pubmed-article:11312329 | pubmed:abstractText | Recombinant bovine/human parainfluenza virus type 3 (rB/HPIV3), a recombinant bovine PIV3 (rBPIV3) in which the F and HN genes were replaced with their HPIV3 counterparts, was used to express the major protective antigens of respiratory syncytial virus (RSV) in order to create a bivalent mucosal vaccine against RSV and HPIV3. The attenuation of rB/HPIV3 is provided by the host range restriction of the BPIV3 backbone in primates. RSV G and F open reading frames (ORFs) were placed under the control of PIV3 transcription signals and inserted individually into the rB/HPIV3 genome in the promoter-proximal position preceding the nucleocapsid protein gene. The recombinant PIV3 expressing the RSV G ORF (rB/HPIV3-G1) was not restricted in its replication in vitro, whereas the virus expressing the RSV F ORF (rB/HPIV3-F1) was eightfold restricted compared to its rB/HPIV3 parent. Both viruses replicated efficiently in the respiratory tract of hamsters, and each induced RSV serum antibody titers similar to those induced by RSV infection and anti-HPIV3 titers similar to those induced by HPIV3 infection. Immunization of hamsters with rB/HPIV3-G1, rB/HPIV3-F1, or a combination of both viruses resulted in a high level of resistance to challenge with RSV or HPIV3 28 days later. These results describe a vaccine strategy that obviates the technical challenges associated with a live attenuated RSV vaccine, providing, against the two leading viral agents of pediatric respiratory tract disease, a bivalent vaccine whose attenuation phenotype is based on the extensive host range sequence differences of BPIV3. | lld:pubmed |
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| pubmed-article:11312329 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11312329 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11312329 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11312329 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11312329 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11312329 | pubmed:month | May | lld:pubmed |
| pubmed-article:11312329 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11312329 | pubmed:author | pubmed-author:MurphyB RBR | lld:pubmed |
| pubmed-article:11312329 | pubmed:author | pubmed-author:SchmidtA CAC | lld:pubmed |
| pubmed-article:11312329 | pubmed:author | pubmed-author:CollinsP LPL | lld:pubmed |
| pubmed-article:11312329 | pubmed:author | pubmed-author:McAuliffeJ... | lld:pubmed |
| pubmed-article:11312329 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11312329 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:11312329 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11312329 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11312329 | pubmed:pagination | 4594-603 | lld:pubmed |
| pubmed-article:11312329 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11312329 | pubmed:meshHeading | pubmed-meshheading:11312329... | lld:pubmed |
| pubmed-article:11312329 | pubmed:meshHeading | pubmed-meshheading:11312329... | lld:pubmed |
