Source:http://linkedlifedata.com/resource/pubmed/id/11312008
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
23-24
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| pubmed:dateCreated |
2001-4-20
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| pubmed:abstractText |
A mutant of Escherichia coli enterotoxin induced cellular immunity to a live varicella vaccine (the Oka strain) as a mucosal adjuvant in mice. The persistence of this cellular immunity was investigated. A commercially available live Oka vaccine virus and toxin were administered once simultaneously via the nasal route, in mice. Ten or 12 months later, a delayed-type hypersensitivity to the vaccine virus was detected by footpad test, but an antibody neutralizing the varicella-zoster virus was not. When spleen cells from mice immunized with the vaccine and toxin were re-stimulated by live vaccine in vitro, their thymidine uptake and IL-2 production were higher than those from mice immunized with the vaccine alone, but lower than those of spleen cells prepared from mice 2 months after nasal administration. Production of IL-4 in these cells, however, was not induced by re-stimulation in vitro. These results suggest that although humoral immunity for Oka vaccine virus is only weakly induced by one co-administration of the vaccine and toxin, cellular immunity is induced and maintained over 1 year, though it declines with age. The nasal administration of the vaccine and toxin might be effective for maintaining cellular immunity to the varicella-zoster virus long term.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Bacterial Toxins,
http://linkedlifedata.com/resource/pubmed/chemical/Chickenpox Vaccine,
http://linkedlifedata.com/resource/pubmed/chemical/Enterotoxins,
http://linkedlifedata.com/resource/pubmed/chemical/Escherichia coli Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-4,
http://linkedlifedata.com/resource/pubmed/chemical/heat-labile enterotoxin, E coli
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
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| pubmed:issn |
0264-410X
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
30
|
| pubmed:volume |
19
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
3131-6
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| pubmed:dateRevised |
2008-8-20
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| pubmed:meshHeading |
pubmed-meshheading:11312008-Administration, Intranasal,
pubmed-meshheading:11312008-Animals,
pubmed-meshheading:11312008-Antibodies, Viral,
pubmed-meshheading:11312008-Bacterial Toxins,
pubmed-meshheading:11312008-Chickenpox Vaccine,
pubmed-meshheading:11312008-Enterotoxins,
pubmed-meshheading:11312008-Escherichia coli,
pubmed-meshheading:11312008-Escherichia coli Proteins,
pubmed-meshheading:11312008-Female,
pubmed-meshheading:11312008-Hypersensitivity, Delayed,
pubmed-meshheading:11312008-Immunity, Cellular,
pubmed-meshheading:11312008-Interleukin-2,
pubmed-meshheading:11312008-Interleukin-4,
pubmed-meshheading:11312008-Lymphocyte Activation,
pubmed-meshheading:11312008-Mice,
pubmed-meshheading:11312008-Mice, Inbred BALB C,
pubmed-meshheading:11312008-Mice, Inbred ICR,
pubmed-meshheading:11312008-Mutation,
pubmed-meshheading:11312008-Time Factors
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| pubmed:year |
2001
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| pubmed:articleTitle |
Long-term persistence of cellular immunity to Oka vaccine virus induced by pernasal co-administration with Escherichia coli enterotoxin in mice.
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| pubmed:affiliation |
Department of Microbiology, Fujita Health University, School of Medicine, Toyoake, 470-1192, Aichi, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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