Source:http://linkedlifedata.com/resource/pubmed/id/11310822
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
2001-4-19
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pubmed:abstractText |
Hodgkin- and Reed-Sternberg (H/RS) cells in classical Hodgkin's disease of the B lineage are the clonal progeny of antigen-experienced B cells harboring highly mutated immunoglobulin variable (V) region genes. Based on the detection of obviously destructive somatic mutations in a fraction of cases, we speculated that H/RS cells may be derived from a pre-apoptotic germinal center B cell. Seemingly contradicting this speculation, we present here the first case of classical Hodgkin's disease with H/RS cells harboring unmutated, potentially functional V region genes, which may indicate the derivation of the H/RS clone from a naive B cell. However, germinal center founder cells, which have not yet acquired somatic mutations, already have the intrinsic propensity to die by apoptosis. Thus, the rare occurrence of H/RS cells with unmutated V genes is expected if the H/RS cells are derived from the pool of pre-apoptotic germinal center B cells.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0023-6837
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
289-95
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:11310822-Aged,
pubmed-meshheading:11310822-Epstein-Barr Virus Infections,
pubmed-meshheading:11310822-Female,
pubmed-meshheading:11310822-Germinal Center,
pubmed-meshheading:11310822-Herpesvirus 4, Human,
pubmed-meshheading:11310822-Hodgkin Disease,
pubmed-meshheading:11310822-Humans,
pubmed-meshheading:11310822-Immunoglobulin Variable Region,
pubmed-meshheading:11310822-Immunophenotyping,
pubmed-meshheading:11310822-Lymph Nodes,
pubmed-meshheading:11310822-Molecular Biology,
pubmed-meshheading:11310822-Mutation,
pubmed-meshheading:11310822-Reed-Sternberg Cells
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pubmed:year |
2001
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pubmed:articleTitle |
Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes.
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pubmed:affiliation |
Institute for Genetics, Department of Immunology, Universität zu Köln, Germany. markus.mueschen@uni-koeln.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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