11309271

Source:http://linkedlifedata.com/resource/pubmed/id/11309271

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0006826, umls-concept:C0031437
pubmed:issue	8
pubmed:dateCreated	2001-4-19
pubmed:abstractText	We have proposed that an early step in tumor progression is the expression of a mutator phenotype resulting from mutations in genes that normally function in the maintenance of genetic stability. There is new and strong experimental evidence that supports the concept of a mutator phenotype in cancer. As technologies for chromosomal visualization and DNA advance, there are increasing data that human cancer cells contain large numbers of mutations. First, I will review the concept of a mutator phenotype. Second, I will present the recent evidence that individual cancer cells contain thousands of mutations. Third, I will explore potential target genes that are required for maintenance of genetic stability in normal cells and ask if they are mutated in cancer cells. Fourth, I will address the timing of a mutator phenotype; is it an early event during tumor progression? Do tumors already contain cells that harbor mutations rendering them resistant to most chemotherapeutic agents? Lastly, I will speculate on the theoretical and practical implication of a mutator phenotype in cancer and consider the possibility of cancer prevention by delay, i.e., a reduction in mutation rates early during carcinogenesis might slow the progression of tumors.
pubmed:grant	http://linkedlifedata.com/resource/pubmed/grant/CA74184, http://linkedlifedata.com/resource/pubmed/grant/CA80993
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/2984705R
pubmed:citationSubset	IM
pubmed:status	MEDLINE
pubmed:month	Apr
pubmed:issn	0008-5472
pubmed:author	pubmed-author:LoebL ALA
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	61
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	3230-9
pubmed:dateRevised	2007-11-14
pubmed:meshHeading	pubmed-meshheading:11309271-Animals, pubmed-meshheading:11309271-Humans, pubmed-meshheading:11309271-Mutation, pubmed-meshheading:11309271-Neoplasms, pubmed-meshheading:11309271-Phenotype
pubmed:year	2001
pubmed:articleTitle	A mutator phenotype in cancer.
pubmed:affiliation	Departments of Pathology and Biochemistry, The Joseph Gottstein Memorial Cancer Research Laboratory, University of Washington, Seattle, WA 98195-7705, USA. laloeb@u.washington.edu
pubmed:publicationType	Journal Article, Research Support, U.S. Gov't, P.H.S., Review