|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1975-8-7
|
|
pubmed:abstractText |
Mice inoculated with MCA-10 sarcoma cells which had previously been incubated with Vibrio cholerae neuraminidase (VCN) demonstrated a significantly lower tumor incidence (9/26) than mice injected with untreated sarcoma cells (10/10) or sarcoma cells incubated with heat-inactivated neuraminidase (28/29) p less than .05. Rechallenge of nontumor-bearing mice from the VCN group with untreated sarcoma cells resulted in a low tumor incidence (4/11), indicating that these mice had developed systemic immunity following the initial injection of VCN-treated tumor cells. These mice also demonstrated significant lymphocytotoxicity against MCA-10 target cells compared with normal control mice (p less than .05). Subsequent cytotoxicity experiments, utilizing groin lymph node and splenic lymphocytes from mice five days following leg injection of VCN-treated, heat-inactivated VCN-treated or untreated MCA-10 cells, demonstrated that the mice injected with VCN-treated tumor cells demonstrated greater antitumor immunity both locally and systemically. This magnification of tumor immunity is postulated as the mechanism by which neuraminidase treated MCA-10 sarcoma cells grew less well in C57 mice than cells incubated with heat-inactivated VCN or cells left untreated.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-4107114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-4338766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-4348470,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-4550256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-4562008,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5021071,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5092115,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5121313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5123336,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5437620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5486608,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5564043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5705148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1130852-5920360
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0003-4932
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
181
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
359-62
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:1130852-Animals,
pubmed-meshheading:1130852-Antibody Formation,
pubmed-meshheading:1130852-Antigens, Neoplasm,
pubmed-meshheading:1130852-Cytotoxicity Tests, Immunologic,
pubmed-meshheading:1130852-Female,
pubmed-meshheading:1130852-Immunization,
pubmed-meshheading:1130852-Lymphocytes,
pubmed-meshheading:1130852-Mice,
pubmed-meshheading:1130852-Neoplasm Transplantation,
pubmed-meshheading:1130852-Neuraminidase,
pubmed-meshheading:1130852-Sarcoma, Experimental,
pubmed-meshheading:1130852-Transplantation, Homologous,
pubmed-meshheading:1130852-Vibrio cholerae
|
|
pubmed:year |
1975
|
|
pubmed:articleTitle |
Antitumor immune response following injection of neuraminidase-treated sarcoma cells.
|
|
pubmed:publicationType |
Journal Article
|
