Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2001-4-18
pubmed:abstractText
Trimethylbenzene (TMB), like xylene (dimethylbenzene), is a significant constituent of some industrial solvent mixtures. In earlier studies, we found that in the rat a subacute low-level inhalation exposure to some of the TMB isomers may result in behavioral alterations detectable weeks after the exposure [Neurotoxicol Teratol 19;1997:327; Int J Occup Med Environ Health 11;1998:319]. The purpose of the present study was to compare m-xylene (XYL) and each of the TMB isomers: 1,2,3-TMB (hemimellitene - HM), 1,2,4-TMB (pseudocumene - PS), and 1,3,5-TMB (mesitylene - MES) with respect to the ability for inducing behavioral effects in the rat. The rats (10-11 animals per group) were exposed repeatedly for 4 weeks (6 h per day, 5 days per week) to XYL (XYL group), HM (HM group), PS (PS group) or MES (MES group) at 100 ppm, or sham exposed (C group) in 1.3 cu/m dynamic inhalation chambers. Starting 2 weeks after exposure the following forms of rat's behavior were assessed: radial maze performance, spontaneous activity in an open field, learning and retention of passive and active (two-way) avoidance response, and heat-induced paw licking before and after a 2 min footshock (a test for assessment of the stress response). None of the solvent-exposed groups differed considerably from the control one with respect to the radial maze performance. Compared to control rats, the rats of the XYL, PS and MES groups, but not those of HM group, showed a significantly higher spontaneous locomotor activity in the open field, an impaired passive avoidance learning and significantly longer paw-lick latencies 24 h after footshock. Acquisition, but not retention, of the two-way active avoidance response was significantly impaired in all solvent-exposed groups. The XYL group did not differ significantly from PS, MES or HM group in any of the behavioral parameters. The above results show that a short-term exposure to any of the TMB isomers or m-xylene at concentration as low as 100 ppm may induce persistent behavioral alterations in the rat.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0161-813X
pubmed:author
pubmed:issnType
Print
pubmed:volume
22
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
79-89
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2001
pubmed:articleTitle
Behavioral effects following subacute inhalation exposure to m-xylene or trimethylbenzene in the rat: a comparative study.
pubmed:affiliation
Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Lód?, Poland. gralslaw@imp.lodz.pl
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't