Source:http://linkedlifedata.com/resource/pubmed/id/11307798
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
2001-4-17
|
| pubmed:abstractText |
In this study of 118 children (median age 5.1 years; range 6 months to 17 years) with ischaemic stroke or transient ischaemic attack (TIA), 22 children (19%) were homozygous for the thermolabile variant of the methylenetetrahydrofolate reductase allele (t-MTHFR), compared with nine of 78 (12%) of a reference population (p=0.18, OR 1.76, 95% CI 0.76 to 4.04). Of those with cerebrovascular disease (CVD), 17 of 84 were homozygous for the t-MTHFR allele (p=0.13 compared with the reference population (OR 1.95, 95% CI 0.81 to 4.65). There was a significant (p<0.025) increment of plasma total homocysteine concentration in homozygotes for the t-MTHFR allele compared with heterozygotes, negatives for the t-MTHFR allele, and control children with no history of stroke. In four of 12 homozygotes for the t-MTHFR allele, plasma homocysteine levels were raised, compared with three of 38 of those who were negative or heterozygous (p=0.047; OR 5.8, 95% CI 1.1 to 31.2). Homozygotes for the t-MTHFR allele were significantly more likely to have a recurrent event than those who were negative or heterozygous (Cox regression p=0.031, hazard ratio 2.18, 95% CI 1.08 to 4.42). These data suggest that homozygosity for the t-MTHFR allele is associated with raised homocysteine levels in children and is a risk factor for primary and secondary stroke and TIA.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Apr
|
| pubmed:issn |
0012-1622
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| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
43
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
220-5
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| pubmed:dateRevised |
2009-11-11
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| pubmed:meshHeading |
pubmed-meshheading:11307798-Adolescent,
pubmed-meshheading:11307798-Alleles,
pubmed-meshheading:11307798-Cerebrovascular Disorders,
pubmed-meshheading:11307798-Child,
pubmed-meshheading:11307798-Child, Preschool,
pubmed-meshheading:11307798-Female,
pubmed-meshheading:11307798-Genetic Predisposition to Disease,
pubmed-meshheading:11307798-Homocysteine,
pubmed-meshheading:11307798-Homozygote,
pubmed-meshheading:11307798-Humans,
pubmed-meshheading:11307798-Infant,
pubmed-meshheading:11307798-Ischemic Attack, Transient,
pubmed-meshheading:11307798-Male,
pubmed-meshheading:11307798-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:11307798-Oxidoreductases Acting on CH-NH Group Donors,
pubmed-meshheading:11307798-Recurrence,
pubmed-meshheading:11307798-Risk Factors,
pubmed-meshheading:11307798-Stroke,
pubmed-meshheading:11307798-Temperature
|
| pubmed:year |
2001
|
| pubmed:articleTitle |
Homozygous thermolabile variant of the methylenetetrahydrofolate reductase gene: a potential risk factor for hyperhomocysteinaemia, CVD, and stroke in childhood.
|
| pubmed:affiliation |
Neurosciences Unit, Institute of Child Health, University College London, UK.
|
| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|