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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2001-4-18
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pubmed:abstractText |
Insulin and multiple other autoantigens have been implicated in the pathogenesis of autoimmune type 1 diabetes, but the origin of immunological self-reactivity specifically oriented against insulin-secreting islet beta-cells remains obscure. The primary objective of the present study was to investigate the hypothesis that a defect in thymic central T-cell self-tolerance of the insulin hormone family could contribute to the pathophysiology of type 1 diabetes. This hypothesis was investigated in a classic animal model of type 1 diabetes, the Bio-Breeding (BB) rat.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1520-7552
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
146-52
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:11307180-Aging,
pubmed-meshheading:11307180-Animals,
pubmed-meshheading:11307180-Animals, Newborn,
pubmed-meshheading:11307180-Diabetes Mellitus, Type 1,
pubmed-meshheading:11307180-Disease Models, Animal,
pubmed-meshheading:11307180-Gene Expression Regulation, Developmental,
pubmed-meshheading:11307180-Immunity, Innate,
pubmed-meshheading:11307180-Immunoradiometric Assay,
pubmed-meshheading:11307180-Insulin,
pubmed-meshheading:11307180-Insulin-Like Growth Factor I,
pubmed-meshheading:11307180-Insulin-Like Growth Factor II,
pubmed-meshheading:11307180-Proinsulin,
pubmed-meshheading:11307180-RNA, Messenger,
pubmed-meshheading:11307180-Rats,
pubmed-meshheading:11307180-Rats, Inbred BB,
pubmed-meshheading:11307180-Rats, Inbred WF,
pubmed-meshheading:11307180-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:11307180-Thymus Gland,
pubmed-meshheading:11307180-Transcription, Genetic
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pubmed:articleTitle |
Thymic expression of insulin-related genes in an animal model of autoimmune type 1 diabetes.
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pubmed:affiliation |
University of Liège, Department of Medicine & Center of Immunology, Institute of Pathology CHU-B23, B-4000 Liège 1-Sart Tilman, Belgium.
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pubmed:publicationType |
Journal Article
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