|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0017337,
umls-concept:C0026882,
umls-concept:C0255732,
umls-concept:C0330390,
umls-concept:C0337112,
umls-concept:C0392756,
umls-concept:C0681850,
umls-concept:C1524075,
umls-concept:C1550501,
umls-concept:C1706203,
umls-concept:C1819433,
umls-concept:C2349001,
umls-concept:C2697811
|
|
pubmed:issue |
1-3
|
|
pubmed:dateCreated |
2001-4-18
|
|
pubmed:abstractText |
The atopic patient has a predisposition to selective synthesis of IgE antibodies to common environmental antigens. IgE production is upregulated by interleukin-4 (IL-4) and downregulated by interferon-gamma (IFN-gamma). IL-12 is a cytokine that induces IFN-gamma production. The signal of IL-12 is transduced through the IL-12 receptor (IL-12R) and Stat4.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1018-2438
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2001 S. Karger AG, Basel
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
124
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
117-20
|
|
pubmed:dateRevised |
2008-11-21
|
|
pubmed:meshHeading |
pubmed-meshheading:11306945-Cells, Cultured,
pubmed-meshheading:11306945-Genetic Predisposition to Disease,
pubmed-meshheading:11306945-Humans,
pubmed-meshheading:11306945-Hypersensitivity, Immediate,
pubmed-meshheading:11306945-Immunoglobulin E,
pubmed-meshheading:11306945-Interferon-gamma,
pubmed-meshheading:11306945-Interleukin-12,
pubmed-meshheading:11306945-Leukocytes, Mononuclear,
pubmed-meshheading:11306945-Models, Immunological,
pubmed-meshheading:11306945-Mutation,
pubmed-meshheading:11306945-Receptors, Interleukin,
pubmed-meshheading:11306945-Receptors, Interleukin-12,
pubmed-meshheading:11306945-Signal Transduction
|
|
pubmed:articleTitle |
Reduced interferon-gamma production and mutations of the interleukin-12 receptor beta(2) chain gene in atopic subjects.
|
|
pubmed:affiliation |
Department of Pediatrics, Gifu University School of Medicine, Gifu, Japan. nkondo@cc.gifu-u.ac.jp
|
|
pubmed:publicationType |
Journal Article
|
