Linked Life Data

11304575

Source:http://linkedlifedata.com/resource/pubmed/id/11304575

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2001-4-17
pubmed:abstractText
Activation of the TCL1 oncogene has been implicated in T cell leukemias/lymphomas and recently was associated with AIDS diffuse large B cell lymphomas (AIDS-DLBCL). Also, in nonmalignant lymphoid tissues, antibody staining has shown that mantle zone B cells expressed abundant Tcl1 protein, whereas germinal center (GC; centrocytes and centroblasts) B cells showed markedly reduced expression. Here, we analyze isolated B cell subsets from hyperplastic tonsil to determine a more precise pattern of Tcl1 expression with development. We also examine multiple B cell lines and B lymphoma patient samples to determine whether different tumor classes retain or alter the developmental pattern of expression. We show that TCL1 expression is not affected by Epstein-Barr virus (EBV) infection and is high in naïve B cells, reduced in GC B cells, and absent in memory B cells and plasma cells. Human herpesvirus-8 infected primary effusion lymphomas (PEL) and multiple myelomas are uniformly TCL1 negative, whereas all other transformed B cell lines tested express moderate to abundant TCL1. This observation supports the hypothesis that PEL, like myeloma, usually arise from post-GC stages of B cell development. Tcl1 protein is also detected in most naïve/GC-derived B lymphoma patient samples (23 of 27 [85%] positive), whereas most post-GC-derived B lymphomas lack expression (10 of 41 [24%] positive). These data indicate that the pattern of Tcl1 expression is distinct between naïve/GC and post-GC-derived B lymphomas (P < 0.001) and that the developmental pattern of expression is largely retained. However, post-GC-derived AIDS-DLBCL express TCL1 at a frequency equivalent to naïve/GC-derived B lymphomas in immune-competent individuals (7 of 9 [78%] positive), suggesting that TCL1 down-regulation is adversely affected by severe immune system dysfunction. These findings demonstrate that TCL1 expression in B cell lymphoma usually reflects the stage of B cell development from which they derive, except in AIDS-related lymphomas.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0023-6837
pubmed:author
pubmed:issnType
Print
pubmed:volume
81
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
555-64
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed-meshheading:11304575-B-Lymphocyte Subsets, pubmed-meshheading:11304575-Cell Line, Transformed, pubmed-meshheading:11304575-Cell Transformation, Viral, pubmed-meshheading:11304575-DNA-Binding Proteins, pubmed-meshheading:11304575-Down-Regulation, pubmed-meshheading:11304575-Gene Expression Regulation, Developmental, pubmed-meshheading:11304575-Gene Expression Regulation, Neoplastic, pubmed-meshheading:11304575-Herpesvirus 4, Human, pubmed-meshheading:11304575-Humans, pubmed-meshheading:11304575-Hyperplasia, pubmed-meshheading:11304575-Lymphoma, AIDS-Related, pubmed-meshheading:11304575-Lymphoma, B-Cell, pubmed-meshheading:11304575-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:11304575-Multiple Myeloma, pubmed-meshheading:11304575-Palatine Tonsil, pubmed-meshheading:11304575-Proto-Oncogene Proteins, pubmed-meshheading:11304575-Proto-Oncogene Proteins c-bcl-6, pubmed-meshheading:11304575-RNA, Messenger, pubmed-meshheading:11304575-Transcription Factors, pubmed-meshheading:11304575-Tumor Cells, Cultured
pubmed:year
2001
pubmed:articleTitle
TCL1 oncogene expression in B cell subsets from lymphoid hyperplasia and distinct classes of B cell lymphoma.
pubmed:affiliation
Department of Pathology, University of California at Los Angeles School of Medicine, 90095-1732, USA.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't