Source:http://linkedlifedata.com/resource/pubmed/id/11304507
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2001-4-17
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| pubmed:abstractText |
In hypertension, both reduced vascular supply and increased cardiac demand contribute to the development of (silent) myocardial ischemia. Our aim was to determine the prevalence of ST-segment depression and to analyze contributing factors in asymptomatic, previously untreated, older hypertensives. From a population survey, in 184 patients with mild hypertension (4 times systolic blood pressure >/=160 mm Hg and/or diastolic blood pressure >/=95 mm Hg), 60 to 75 years of age, cardiovascular end-organ damage was measured. Episodes of ST-segment depression were measured by 48-hour ambulatory Holter monitoring and were observed in 21 hypertensives (12%). They showed a significantly higher combined far-wall intima-media thickness of carotid and femoral arteries and more arterial plaques as measured by B-mode ultrasound compared with hypertensives without ST depression (0.00098+/-0.00021 versus 0.00088+/-0.00016 mm and 5.2+/-3.7 versus 3.7+/-2.8 plaques, P<0.05, respectively), whereas left ventricular mass index was not different (111+/-18 versus 104+/-24 g/m(2); P=0.18, respectively). In hypertensives with transient ST-segment depression, a significant relation was found between left ventricular mass and ischemic burden (r=0.51, P=0.02). Approximately 1 of 8 unselected and previously untreated older hypertensives show asymptomatic ST-segment depression, suggestive of silent myocardial ischemia. These data suggest that vascular factors mainly determine the occurrence of ischemic ST-segment depression and cardiac factors determine the ischemic burden in older hypertensives.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
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| pubmed:issn |
1524-4563
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
37
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
1083-8
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| pubmed:dateRevised |
2004-11-17
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| pubmed:meshHeading |
pubmed-meshheading:11304507-Aged,
pubmed-meshheading:11304507-Arteriosclerosis,
pubmed-meshheading:11304507-Carotid Arteries,
pubmed-meshheading:11304507-Circadian Rhythm,
pubmed-meshheading:11304507-Echocardiography,
pubmed-meshheading:11304507-Electrocardiography,
pubmed-meshheading:11304507-Electrocardiography, Ambulatory,
pubmed-meshheading:11304507-Female,
pubmed-meshheading:11304507-Femoral Artery,
pubmed-meshheading:11304507-Humans,
pubmed-meshheading:11304507-Hypertension,
pubmed-meshheading:11304507-Male,
pubmed-meshheading:11304507-Middle Aged,
pubmed-meshheading:11304507-Myocardial Ischemia,
pubmed-meshheading:11304507-Regression Analysis
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| pubmed:year |
2001
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| pubmed:articleTitle |
Silent ST depression and cardiovascular end-organ damage in newly found, older hypertensives.
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| pubmed:affiliation |
Department of Cardiology/Thoraxcenter, University Hospital Groningen, The Netherlands. w.f.terpstra@castel.nl.
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| pubmed:publicationType |
Journal Article
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