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pubmed-article:11303872pubmed:abstractTextThe synthesis of a 93-residue chemokine, lymphotactin, containing eight sites of O-linked glycosylation, was achieved using the technique of native chemical ligation. A single GalNAc residue was incorporated at each glycosylation site using standard Fmoc-chemistry to achieve the first total synthesis of a mucin-type glycoprotein. Using this approach quantities of homogeneous material were obtained for structural and functional analysis.lld:pubmed
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pubmed-article:11303872pubmed:articleTitleChemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.lld:pubmed
pubmed-article:11303872pubmed:affiliationDepartment of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA.lld:pubmed
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