rdf:type |
|
lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2001-4-16
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pubmed:abstractText |
The synthesis of a 93-residue chemokine, lymphotactin, containing eight sites of O-linked glycosylation, was achieved using the technique of native chemical ligation. A single GalNAc residue was incorporated at each glycosylation site using standard Fmoc-chemistry to achieve the first total synthesis of a mucin-type glycoprotein. Using this approach quantities of homogeneous material were obtained for structural and functional analysis.
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pubmed:language |
eng
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pubmed:journal |
|
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines, C,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Cell Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Sialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/XCL1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/XCR1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/lymphotactin
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
|
pubmed:issn |
0947-6539
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pubmed:author |
|
pubmed:issnType |
Print
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pubmed:day |
2
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1129-32
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pubmed:dateRevised |
2009-8-4
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pubmed:meshHeading |
pubmed-meshheading:11303872-Amino Acid Sequence,
pubmed-meshheading:11303872-Biochemistry,
pubmed-meshheading:11303872-Cells, Cultured,
pubmed-meshheading:11303872-Chemokines, C,
pubmed-meshheading:11303872-Glycosylation,
pubmed-meshheading:11303872-Humans,
pubmed-meshheading:11303872-Kidney,
pubmed-meshheading:11303872-Lymphokines,
pubmed-meshheading:11303872-Magnetic Resonance Spectroscopy,
pubmed-meshheading:11303872-Membrane Proteins,
pubmed-meshheading:11303872-Molecular Sequence Data,
pubmed-meshheading:11303872-Protein Conformation,
pubmed-meshheading:11303872-Receptors, Cell Surface,
pubmed-meshheading:11303872-Receptors, G-Protein-Coupled,
pubmed-meshheading:11303872-Sialoglycoproteins
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pubmed:year |
2001
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pubmed:articleTitle |
Chemical synthesis of lymphotactin: a glycosylated chemokine with a C-terminal mucin-like domain.
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pubmed:affiliation |
Department of Chemistry, Howard Hughes Medical Institute, University of California, Berkeley 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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